Effect of Ethanol Extract of Coccinia grandis Lin leaf on Glucose and Cholesterol Lowering Activity

Md. Mamun Al-Amin *

Department of Pharmacy, North South University, Bashundhara, Dhaka 1229, Bangladesh.

Mir Muhammad Nasir Uddin

Department of Pharmacy, University of Chittagong, Chittagong 4331, Bangladesh.

Ashfique Rizwan

Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.

Md. Siddiqul Islam

Department of Pharmacy, Manarat International University, Dhaka 1212, Bangladesh.

*Author to whom correspondence should be addressed.


Abstract

Aims: To investigate the effect of ethanol extract of Coccinia grandis Lin (Cucurbitaceae) leaf in glucose and cholesterol lowering activity in animal model.
Study Design: Extraction, glucose and cholesterol lowering activity evaluation.
Place and Duration of Study: Department of Pharmacy, North South University, Dhaka between June 2012 and December 2012.
Methodology: Glucose and cholesterol lowering effect of the ethanol extract of C. grandis leaf was evaluated using the alloxan-induced diabetic rat and compared the activity with diabetic control and antidiabetic drug (Glibenclamide). Ethanol extract (25mg/kg) of C. grandis and Glibenclamide were administered to normal and experimental diabetic rats for the duration of 10 days.
Results: Phytochemical screening showed the presence of alkaloids, flavonoids, saponins, cardenolides and polyprenols in significant amounts. In the alloxan-induced diabetic rat model, C. grandis (25 mg/kg) significantly (p<0.05) lowered fasting blood glucose levels. C. grandis extract (25 mg/kg) also produced significant (p<0.05) total cholesterol lowering and HDL increasing (p<0.05) effects. Surprisingly, body weight was increased significantly (p<0.05) in the C. grandis treated diabetic group.
Conclusion: These results suggest that the ethanol extract of C. grandis leaf possesses significant glucose and cholesterol lowering activity in animal model, thus supporting the usage of the plant in traditional medicine as an anti-diabetic medication.

Keywords: Antidiabetic activity, glibenclamide, coccinia grandis.


How to Cite

Al-Amin, M. M., Nasir Uddin, M. M., Rizwan, A. and Islam, M. S. (2013) “Effect of Ethanol Extract of Coccinia grandis Lin leaf on Glucose and Cholesterol Lowering Activity”, Journal of Pharmaceutical Research International, 3(4), pp. 1070–1078. doi: 10.9734/BJPR/2013/4583.