Evaluation of Antihyperlipidemic Activity of Choerospondias axillaris in Rats
Jeevan Khadka *
Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.
Kusu Susan Cyriac
Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.
Ali Salman Al-Shami
Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.
Zohreh Elyasi
Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.
Blessy Elizabeth Babukutty
Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Choerospondias axillaris CA, known as lapsi, is a plant with constituents having therapeutic properties. All plant parts including stem, bark, root, leaves, and fruit have medicinal virtues and have had a role in Ethno-medicine since ancient times.
Objective: The present study was designed to investigate the antihyperlipidemic activity of dried powder of Choerospondias axillaris fruits in Wistar albino rats.
Methods: The anti-hyperlipidemic effect of methanolic extract of the fruit of Choerospondias axillaris (CA) was tested in a high-fat diet-induced hyperlipidemic rat model. Here, chronic hyperlipidemia was induced by feeding a high-fat diet for 21 days to rats. During the experiment, the rat’s body weight was monitored. At the end of the study, animals among whole groups have been sacrificed and biochemical parameters such as; serum Total Cholesterol, Triglycerides, Low-Density Lipoprotein Cholesterol (LDL-C), Very Low-Density Lipoprotein Cholesterol (VLDL-C), and increase of serum High-Density Lipoprotein Cholesterol (HDL-C) were analysed.
Results: The observed extract of Choerospondias axillaris was proven to be safe in the toxicity findings. Treatment with methanolic extract of CA (200 and 400 mg/kg, p.o) significantly reduced the hyperlipidemia i.e., the decline in levels of serum Total Cholesterol, Triglycerides, Low-Density Lipoprotein Cholesterol (LDL-C), Very Low-Density Lipoprotein Cholesterol (VLDL-C), and High-Density Lipoprotein Cholesterol (HDL-C) when compared to vehicle control and standard drug Atorvastatin (10 mg/kg). The result indicates that methanolic extract of the whole plant of Choerospondias axillaris possessed significant antihyperlipidemic activity.
Conclusion: After all the investigation it was found that oral administration of Choerospondias axillaris fruit extract at a low dose of 300mg/kg and a high dose of 600mg/kg against the high-fat diet-induced hyperlipidemia and it was found that a high dose was more effective as compared to low dose. The drug was able to suppress the raised parameters.
Keywords: High-fat diet, hyperlipidemia, Choerospondias axillaris, rats, Atorvastatin