Evaluation of Antihyperlipidemic Activity of Choerospondias axillaris in Rats

Jeevan Khadka *

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.

Kusu Susan Cyriac

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.

Ali Salman Al-Shami

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.

Zohreh Elyasi

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.

Blessy Elizabeth Babukutty

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India.

*Author to whom correspondence should be addressed.


Background: Choerospondias axillaris CA, known as lapsi, is a plant with constituents having therapeutic properties. All plant parts including stem, bark, root, leaves, and fruit have medicinal virtues and have had a role in Ethno-medicine since ancient times.

Objective:  The present study was designed to investigate the antihyperlipidemic activity of dried powder of Choerospondias axillaris fruits in Wistar albino rats.

Methods: The anti-hyperlipidemic effect of methanolic extract of the fruit of Choerospondias axillaris (CA) was tested in a high-fat diet-induced hyperlipidemic rat model. Here, chronic hyperlipidemia was induced by feeding a high-fat diet for 21 days to rats. During the experiment, the rat’s body weight was monitored. At the end of the study, animals among whole groups have been sacrificed and biochemical parameters such as; serum Total Cholesterol, Triglycerides, Low-Density Lipoprotein Cholesterol (LDL-C), Very Low-Density Lipoprotein Cholesterol (VLDL-C), and increase of serum High-Density Lipoprotein Cholesterol (HDL-C) were analysed.

Results: The observed extract of Choerospondias axillaris was proven to be safe in the toxicity findings.  Treatment with methanolic extract of CA (200 and 400 mg/kg, p.o) significantly reduced the hyperlipidemia i.e., the decline in levels of serum Total Cholesterol, Triglycerides, Low-Density Lipoprotein Cholesterol (LDL-C), Very Low-Density Lipoprotein Cholesterol (VLDL-C), and High-Density Lipoprotein Cholesterol (HDL-C) when compared to vehicle control and standard drug Atorvastatin (10 mg/kg). The result indicates that methanolic extract of the whole plant of Choerospondias axillaris possessed significant antihyperlipidemic activity.

Conclusion: After all the investigation it was found that oral administration of Choerospondias axillaris fruit extract at a low dose of 300mg/kg and a high dose of 600mg/kg against the high-fat diet-induced hyperlipidemia and it was found that a high dose was more effective as compared to low dose. The drug was able to suppress the raised parameters.

Keywords: High-fat diet, hyperlipidemia, Choerospondias axillaris, rats, Atorvastatin

How to Cite

Khadka, J., Cyriac, K. S., Al-Shami, A. S., Elyasi, Z. and Babukutty, B. E. (2022) “Evaluation of Antihyperlipidemic Activity of Choerospondias axillaris in Rats”, Journal of Pharmaceutical Research International, 34(51B), pp. 1–11. doi: 10.9734/jpri/2022/v34i51B7204.


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Kolovou GD, Anagnostopoulou KK, Cokkinos DV. Pathophysiology of dislipidaemia in the metabolic syndrome. Postgraduate Medical Journal. 2005; 81(956):358-366.

Stone NJ. Lipid management: current diet and drug treatment options,”The American Journal of Medicine. 1996;101(4):40S-49S.

Lin Y, Mousa SS, Elshourbagy N, Mousa SA. Current status and future directions in lipid management: emphasizing low-density lipoproteins, high-density lipoproteins and triglycerides as target for therapy. Vascular Health and Risk Management. 2010;6(1):73-85.

Kobayashi M, Kagawa T, Narumi K, Itagaki S, Hirano T, Iseki K. Bicarbonate supplementation as a preventive way in statins-induced muscle damage. Journal of Pharmacy and Pharmaceutical Sciences. 2008;11(1):1-8.

Guyton JR, Bays HE. Safety considerations with niacin therapy. The American Journal of Cardiology. 2007; 99(6):S22-S31.

Paudel KC, Pieber K, Klump R and Laimer M: Evaluation of Lapsi tree (Choerospondias axillaris) for fruit production in Nepal. Bodenkultur. 2003; 54(1);23-27.

Paudel K, Pieber K, Klumpp R, and Laimer M. Collection and evaluation of germplasm of lapsi (Choerospondias axillaris), B.L. Burtt and A.W. Hill), an indigenous fruit tree of Nepal. Plant Genetic Resources Newsletter. 2002;130(1):36-46.

Zhu Lian, Chengzhong Zhang, Chong Li, Yawei Zhou. [Studies on chemical constituents of Choerospondias axillaris]. Zhong Yao Cai 2003;26(1):23-24.

Yue X, C Juntao, Yang Y, Liu Z, Wang T. Chemical components of Choerospondias axillaris wood by TD-GC/MS, Py-GC/MS, and TG. Journal of King Saud University-Science. 2020;32(1):1142-1146.

Labh SN, Shakya SR, Kayasta BL. Extract of Medicinal lapsi Choerospondias axillaris (Roxb.) exhibit antioxidant activities during in vitro studies. Journal of Pharmacognosy and Phytochemistry. 2015;4(3):194-197.

Mann S, Sharma A, Sarkar A, Kharb R. Evaluation of Anti-inflammatory effects of Choerospondias axillaris Fruits Methanolic Extract in Synoviocytes and CIA Rat Model. Curr Pharm Biotechnol. 2020;21(7):596-604.

Yun-Seo Kl, Risinger AL, Petersen CL, Liang H, Grkovic TN, Barry R. O’Keefe, Mooberry SL, Cichewicz RH. Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris. J. Nat. Prod. 2020;83(3):584–592.

Lei CH, Jie HE, Gao YN, Xing YN. Preventive Effect of Total Flavones of Choerospondias axillaries on Ischemia/Reperfusion-Induced Myocardial Infarction-Related MAPK Signaling Pathway. Cardiovascular Toxicology. 2013; 14(2):210-216.

Mukherjee PK. Quality control of herbal drugs, an approach to evaluation of Botanicals. 1st Ed. New Delhi: Business horizons. 2002;5(1):379-401.

Khandelwal KR. Practical Pharmacognosy. Techniques and experiments. Nirali Prakashan. 2008;1(11):149-53.

S.R Brahma and C.H Saileela. Anti-hyperlipidemic activity of methanolic extract of Rhinacanthus Nasutus. International Journal of Research in Pharmacy and Chemistry. 2013;3(3): 708-11.

LIU Xin-yuan, YANG Yu-mei, HAN Feng, ZHANG Hao-nan, DU Jian-xi, HAO Xin-min. Immunological Effects of Total Flavones from Leaves of Choerospondias axillaris on Mice. Chinese Herbal Medicines. 2013;5(2):121-124.

Mukesh SS, MB. Antihyperlipidemic activity of Salacia chinensis root extracts in triton induced and atherogenic diet-induced hyperlipidemic rats. Indian J Pharmacol. 2012;44(1):88-92

Vilasinee H, Anocha U, Noppawan PM, Nuntavan B, Hitoshi S, Angkana H and Chuthamanee S. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol. 2006;103(2):252-260.