Extended Release Niosomal Hydrogel for Ocular Targeting of Piroxicam: In vitro and Ex vivo Evaluation
Bazigha K. Abdul Rasool *
Department of Pharmaceutics, Dubai Pharmacy College, Dubai, United Arab Emirates.
Oday S. Azeez
Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Basrah, Iraq.
Hamda A. Lootah
BPharm, Dubai Pharmacy College, Dubai, United Arab Emirates.
Iman M. Abusharbain
BPharm, Dubai Pharmacy College, Dubai, United Arab Emirates.
Hiba A. Abu-Alhaj
BPharm, Dubai Pharmacy College, Dubai, United Arab Emirates.
Fazilatun Nessa
Department of Pharmaceutical Chemistry and Natural Products, Dubai Pharmacy College, Dubai, United Arab Emirates.
*Author to whom correspondence should be addressed.
Abstract
This study aimed at the investigation of piroxicam-niosomal hydrogel for ocular targeting to prolong and enhance its local analgesic activity. Various formulations were prepared, characterized and evaluated ex vivo for their transocular permeation using excised cow cornea. The prepared niosomes had distinct spherical multi-lamellar shape and mean vesicle size between 1.25±0.81μm and 7.47±0.85μm. Relevant increase in drug EE% was obtained with increase of cholesterol content and surfactant’s hydrophobicity. Drug retention in vesicles was significantly (p<0.05) higher at refrigerated condition than that at the room temperature. Prolonged drug release was achieved with high niosomal cholesterol content and the mechanism of drug release can be described as Fickian diffusion. The niosomal hydrogel showed 3.7 Permeability Improvement Ratio comparing to piroxicam aqueous suspension. The optimized niosomal gel showed prolonged drug release and enhanced piroxicam ocular bioavailability due to the formation of an amorphous drug form within the gel.
Keywords: Piroxicam, niosomes, span surfactants, hydrogel, ocular, bioavailability, extended release