Journal of Pharmaceutical Research International

Objective: To relieve postoperative pain and nausea and vomiting, various drugs and methods, including intraoperative IV lidocaine infusion in different surgeries. However, the exact dose has not yet been determined. The purpose of this study was to evaluate and compare the effect of intraoperative 1 mg/kg/h and 2 mg/kg/h IV lidocaine infusion on postoperative pain and nausea-vomiting in laparoscopic gastric bypass surgery.

Methods: This clinical trial study was performed on patients undergoing laparoscopic gastric bypass surgery in Rasoul-e-Akram Hospital, Iran. Patients were randomly assigned into two groups (1 mg/kg/h lidocaine) and (2 mg/kg/h lidocaine). Postoperative pain and nausea and vomiting were evaluated at times 0, 30 min, 1 h, 6 h, 12 h and 24 h after surgery. Data was analysed using statistical tests and SPSS 22.

Results: There was no significant difference in the effect of intraoperative 1 mg/kg/h and 2 mg/kg/h IV lidocaine infusion on static and dynamic pain and nausea-vomiting, agitation, systolic BP, diastolic BP, pulse rate and postoperative administration of pethidine in laparoscopic gastric bypass (P>0.05).

Conclusion: Based on results of this study, administration of low dose lidocaine (1 mg/kg/h) can be considered as an appropriate dose of IV lidocaine infusion in order to control postoperative pain and nausea and vomiting in laparoscopic gastric bypass surgery.