Lipidomic Profiling Disturbance as Good Follow up Index in Obese Diabetic Patients
Rukaiah M. Almahmoudi
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Abdulrahman L. Al-Malki
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Bioactive Natural Products Research Group, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Said S. Moselhy *
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Bioactive Natural Products Research Group, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Jeddah, Saudi Arabia and Department of Biochemistry, Faculty of Science, Ain Shams University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Background: Metabolite profiling, or metabolomics, has become a powerful approach that has been widely adopted for clinical diagnostics. This study aimed to evaluate the metabolomics profile in obese and obese diabetic patients as the early predictor of diabetes with obese patients.
Subjects and Methods: This study was conducted on fifty-four from one hundred and sixty unrelated individuals. Participants were mainly 35–70 years of age were classified to four groups are normal, obese and obese diabetic, obese.
Results: It was found a significant increase in mean values of LDL concentration in obese as compared to healthy group. It also found that, in obese subjects with the metabolic syndrome and T2D, oxidative stress is increased and the redox state is a potentially useful therapy. Some lipid metabolism-related metabolites, including saturated fatty acides, palmitate and stearate and unsaturated fatty acid archidonic acid, have been identified in diabetic, which indicate a dysregulation of lipid metabolites in diabetic subjects.
Conclusion: In conclusion, metabolomics of lipid intermediate was considered as good index of metabolic syndrome and diabetes and can be taken in consideration for follow up and treatment.
Keywords: Obesity, diabetic, metabolomics