Open Access Systematic Review Article

Medico-social Aspects of Dental Care for Geriatric Patients

Nina Musurlieva, Tanya Bozhkova

Journal of Pharmaceutical Research International, Page 35-44
DOI: 10.9734/jpri/2022/v34i19B35817

Geriatric patients are a specific group because of their susceptibility to physiological, psychological, social, and health-related problems. Uncovering the modern character of a geriatric patient, the specifics of aging in a bio-psycho-social aspect, additional medical qualifications, and acquisition of competence bettering healthcare for these patients is necessary when taking into consideration the persisting tendency for demographic aging. The objective of this study is to outline the general medico-social aspects of dental care for geriatric patients. A comprehensive literature search was conducted, mainly using PubMed and Embase, which was limited to publications written in English over the past 10 years (2010–2020). Oral health is an essential topic in geriatric preventive medicine, with direct as well as indirect effects on the overall health and quality of life of the individual. Surveillance and improvement of the oral health of the elderly should be a key objective of the multidisciplinary team responsible for their care, including dentists, dental hygienists, geriatricians, and caregivers.

Open Access Case Study

A Intresting Case of Struge Weber Syndrome

Vikram Vikhe, Prakash Shende, Harish Choudhari, Ridhima Jakotia

Journal of Pharmaceutical Research International, Page 15-20
DOI: 10.9734/jpri/2022/v34i19B35814

Struge Weber Syndrome is a rare neurocutaneous disorder characterized by Leptomeninigeal & facial angiomas mainly in the course of ophthalmic& maxillary branches of the trigeminal nerve. We report a case of 14 year old male who presented with left hemiparesis since 2 to 3months & Generalized tonic clonic seizures since 5days.Diagnosis is confirmed by CT/MRI. The classical findings seen on CT/MRI are atrophy and calcification of the cerebral hemisphere. The most common neurological symptom seen are seizures, they are typically focal tonic clonic seizures, seen during first year of life. They are often refractory to anti-convulsants. Most children present with slowly progressive hemiparesis during the course of illness.

Open Access Original Research Article

Isolated Pattern of Microorganism among Pediatric Patients with Ventilator-associated Pneumonia (VAP) in a Tertiary Care Hospital Karachi

Faiza Khan, Maqsood Ahmed Khan, Shazia Alam, . Zeb-Un-Nisa, Bisma Kafeel, . Shumail, Sara Shafiq, Muhammad Gulraiz, Saira Shahnaz

Journal of Pharmaceutical Research International, Page 1-8
DOI: 10.9734/jpri/2022/v34i19B35805

Background: The Ventilator associated pneumonia (VAP) is a common condition with inflammation of lungs. The patients on mechanical ventilation or artificial breathings for 48 to 72 hours tend to developed this condition., which is a type of Nosocomial Pneumonia.

Objective: To assess the causative agent and treatment pattern among the patients suffering from ventilator associated pneumonia.

Methodology: A cross sectional study was conducted for the period of 8 months at a tertiary health care setup of the Karachi Pakistan among the patient’s with VAP. Total of 72 patients with confirmed diagnosis of VAP were included in the study. Data was collected from the children intensive care units on a structed questionnaire. The required variables were obtained from the patients files/Records after the ethical approval was obtained before the collection of data Results were evaluated using the SPSS version 20.0.

Results: The study found out that the VAP is most type of hospital acquired pneumonia form the health care system., showed 59.8% (n=61) males and 34.3% (n=35) females’ patients with VAP diagnosis. The age group revealed majority of the patients 46.1% (n=47) were 0–1-year-old, 11.8% (n=12) patients were above 2- 3 years old. 18.6% patients (n=19) were >3 years-4years old. The study also assesses ventilators support >48 hours have around 20-30% (Mean 6.9 days CI: 1.16-3.65) chance to develop the VAP. The subsequent effects of VAP shows the two-fold rates of mortality hence requiring the more length of stay at hospital and extra charges.

Conclusion: The VAP occurs among the considerable numbers of patients on the ventilator supports, the findings suggests that an appropriate management, prevention strategies and effective treatment is needed to reduces the mortality and complications of VAP.

Open Access Original Research Article

Prevalence and Pattern of Cancer in the Northern Border Region of Saudi Arabia-Arar

Ahmed M. Aljameeli

Journal of Pharmaceutical Research International, Page 21-29
DOI: 10.9734/jpri/2022/v34i19B35815

Introduction: There is a substantial rise in the incidence of cancer in Saudi Arabia. The aim of this study was conducted to determine the demographic, prevalence, and pattern of cancer in the Northern Border region of Saudi Arabia-Arar.

Methods: The record of 88 histologically confirmed cancer cases was retrieved and studied from files of the oncology department, Prince Abdul-Aziz Ibn Musaad hospital, Arar, Kingdom of Saudi Arabia (KSA).

Results: The most common cancers in the whole population irrespective of sex were carcinoma of the leukemia, breast, lymphoma and leukemia combined and colorectal cancer. The most common cancers in females in Northern Border region were those of the breast, thyroid, and lymphomas and leukemia combined. Comparative findings for males were lymphomas and leukemias combined colorectal cancers.

Conclusion: The present study showed a high prevalence and pattern of cancer in Northern Border region, Saudi Arabia according to gender, age, frequency, and type of cancer.

Open Access Review Article

A Review on Role of Zebrafish in Huntington’s Disease

Bhumi Chaturvedi, Shambaditya Goswami, Hemant Bareth, Akhilesh Patel, Rajesh Kumar Sharma, Deepak Nathiya, Arjav Jain, Nikita Pal

Journal of Pharmaceutical Research International, Page 9-14
DOI: 10.9734/jpri/2022/v34i19B35806

Treatment and effective therapies of most of the neurodegenerative disease are not available due to social and economic factors which makes it incurable. Huntington’s disease is one of such disease. Huntington’s disease (HD) is an inherited condition which leads to progressive degeneration of nerve cells may leads to cognitive, behavioral, and psychiatric symptoms. Discovery of zebrafish has filled the gap between in vitro and in vivo assays and makes the study of neuroscience easy with less complications. Zebrafish model has become a recent topic to focus on, as its utility in the study of neurological disease and role in improving screening methods makes the treatment and therapies more productive. Zebrafish hold many advanced functional genomics like human disease, the understanding of genetics, neurodegenerative disease and disorders and the discovery of therapeutics. It assess the mutant gene, etiology of human’s disease, and it is role in the disease progression and allows the identification of relevant treatment for the same. This review highlights the role of the zebrafish in the Huntington’s disease.

Open Access Review Article

Virtue of Coenzyme Q10 as an Antioxidant Drug in Periodontal Disease : A Review

Tamil Selvan Kumar, J. Maria Beulah, Gokulvathi Rajkumar, S. Divya, M. Ahamed Faizal, A. S. Hari Prasat

Journal of Pharmaceutical Research International, Page 30-34
DOI: 10.9734/jpri/2022/v34i19B35816

Periodontal disease is a disease of inflammatory origin. In the oxidative phosphorylation process for ATP generation, coenzyme Q10 (CoQ10) plays a vital role. Coenzyme Q10 is a vital antioxidant. In cellular bioenergetics, the coenzyme Q10 plays a major role. Because of its large molecular weight and its medicinal properties, the absorption of dietary coenzyme Q10 has numerous therapeutic application in human diseases. Evidence of beneficial effect in cardiovascular and neuro degenerative disease were noted and it was found that Q10 has superior safety record. This article gives the relation of CoQ10 to the periodontal disease.