Open Access Study Protocol
Aim of the Study: To assess the effectiveness of self-instructional module on healthy sleep hygiene habits on quality of sleep, among arthritis patients.
Study Design: The design that will be used in the study is One Group Pre Test Post Test research design.
Methodology: A study used a pre-test post-test design with no control group and a pre-experimental design. The study will be conducted during December 2021 to May 2021.The impact of self-instructional module on healthy sleep hygiene habits on quality of sleep, among arthritis patients will be assessed using the purposive sampling technique. In this study Evaluatory research approach will be used. Selected 140 arthritis patients will be assessed primarily for knowledge by giving structured questionnaires regarding healthy sleep hygiene habits and then self-instructional module on healthy sleep hygiene habits on quality of sleep, will be given to the selected sample developed by researcher as intervention.
Expected Results: To assess the effectiveness of self-instructional module on healthy sleep hygiene habits on quality of sleep, among arthritis patients. In this study self-instructional module on healthy sleep hygiene habits on quality of sleep will be useful in improving the arthritis patient’s knowledge.
Conclusion: The conclusion will be drawn from the results and will be published in per review journal.
Open Access Original Research Article
Appropriate cell models are the foundation of cancer research as all the cell lines are not the same in their ability to mimic primary tumor tissue. Molecular characteristics of various cell lines can help in selecting the right cell model for biomedical studies. This study describes the gene expression profile of nine genes, include the six-protein shelterin complex, tankyrases1and 2, and CTNNB1 in three different models of human colon cancer cell lines. Also, the relative telomere length in each cell line was evaluated. All genes' expression levels were analyzed using a real-time polymerase chain reaction. Nearly all test genes were significantly highly expressed in HT-29 as compared to HCT-116 and SW-620. SW-620 record a significantly increased expression of the CTNNB1 gene (P-value < 0.01) while most genes were poorly expressed in HCT-116. A positive correlation between CTNNB1 and hTERT expression was found in HCT-116 and SW-620 but not in HT-29. Telomere was found to be of the same length in all cell. Gene expression data presented in our results can assist in selecting appropriate cell lines in colon cancer research. Unique molecular properties of various cancer cell lines should be evaluated before selecting a cell line mmodelfor research purposes.
Open Access Original Research Article
The novel coronavirus (COVID-2019) has spread very rapidly all over the globe, causing an outbreak of acute infectious pneumonia. This pandemic brought not only the risk of death but also psychological pressure on people and remarkably on college students. To assess the psychological impact of COVID-19 on college students. A web-based cross-sectional study was conducted on college students studying diploma, graduation, and post-graduation irrespective of their gender was included in the study. The data was collected through online mode by providing links to fill google form. The survey tool was disseminated in various messenger groups and social media networks. The survey tool comprises demographics, COVID-19 stressors, generalized anxiety disorder scale (GAD 7), and patient health questionnaire (PHQ 9) scale. Chi-square was used to find the association between demographic characters with anxiety and depression. 443 students participated in this web-based survey. Among all participants, 44.25% were normal range, 31.38% are mild anxiety, 18.97% were moderate anxiety, and 5.42% were severe anxiety. Results also indicated that there were 37.25% participants were in normal range, about 27% were mild depression, 22.13% moderate depression, 7.45% moderately severe depression and 6.1% severe depression. All the variables other than gender, place of residence, and steady family income were significantly associated with anxiety, whereas gender and place of residence variables were not significantly associated with depression. To conclude, the mental health of college students was significantly affected by the pandemic. More help and support from society, families and colleges would be supportive to them. It is suggested that the government and colleges should collaborate to resolve this problem by providing high-quality, timely crisis oriented psychological services to college students.
Open Access Review Article
Objective: To compare the rate of complications encountered on using different incision to access the fracture site for the open reduction and internal fixation of condylar fractures.
Setting: Department of Oral & Maxillofacial Surgery, Institute of Dentistry, LUMHS
Subject and Methods: A total 64 patients with unilateral condyle fractures were randomly treated into two groups. Thirty two patients in group A were treated with preauricular incision and 32 were treated with Retro mandibular incision. Patients were followed for period of upto six months for assessment of complications of facial nerve injury such as: salivary fistula and hypertrophic scar formation.
Results: The average age of the patients was 31.66±9.40 years. Rate of facial nerve palsy was significantly high in group A than group B (18.75% vs. 6.25%; p=0.021) similarly, the rate of salivary fistula and scar formation were also significantly high in group A as compare to groups B (12.5% vs. 1.56% p=0.026) and (14.06% vs. 1.56%;p=0.013) respectively.
Conclusion: The retromandibular approach is more suitable for the lower level condylar neck fractures, providing a direct visual field and wide, straight-line access for implant fixation at this region.