Improve Markers of Oxidative Stress and Coagulation Parameters in Response to Atorvastatin Therapy
Bassim I. Mohammad
College of Pharmacy, University of Al Qadisiyah, Iraq.
Najah R. Hadi
Department of Pharmacology, College of Medicine, University of Kufa, Iraq.
Haider M. Jawad
Department of Pharmacology, College of Medicine, University of Kufa, Iraq.
Dina A. Jamil
School of Community Health and Centre for Research in Complex Systems, Charles Sturt University, NSW, Australia.
Hayder A. Al-Aubaidy *
School of Community Health and Centre for Research in Complex Systems, Charles Sturt University, NSW, Australia and School of Medicine, University of Tasmania, Hobart, Australia.
*Author to whom correspondence should be addressed.
Abstract
Aims: This study was undertaken to investigate the antioxidant effects of atorvastatin in treating cases of atherosclerosis associated with hyperlipidemia.
Methodology: Forty local domestic rabbits were assigned to five groups (eight rabbits in each group): After two weeks acclimatization period, a group of 8 rabbits (Group I) were used as the baseline values of the study parameters. Another 8 rabbits were selected and maintained on standard chow diet (4% fat, 18% protein, 60% carbohydrate, and 4% fibers) throughout the experiment (12 weeks) and served as a normal diet control (Group II). The rest 24 rabbits were fed on an atherogenic diet for 8 weeks to induce atherogenesis. At the end of 8th week, a group of 8 atherogenic rabbits (Group III) were separated and sacrificed and served as an atherogenic-baseline group. The remaining 16 atherogenic rabbits were randomly allocated into two groups; first group received atherogenic diet only for the next four weeks and served as an atherogenic control (Group IV). The other group received atorvastatin (Group V).
Results: Blood samples were collected for serum lipids, coagulation parameters and oxidation parameters. Results showed a significant improvement in the coagulation parameters and oxidation parameters in the atorvastatin treated group compared to the atherogenic control group (P= .01).
Conclusion: This study illustrated the beneficial anti-oxidant effects of atorvastatin in treating atherosclerosis associated with hyperlipidemia.
Keywords: Atorvastatin, coagulation, oxidative stress, antioxidants, atherosclerosis