Correlation between Peak Expiratory Flow Rate and Single Breath Count in Patients with Post-COVID Sequelae: An Observational Study

D. Sarmila *

Visakha Academy of Physiomedical Sciences, Bakkannapalem, Visakhapatnam, Andhra Pradesh – 530048, India.

N. Rama Tulasi

Visakha Academy of Physiomedical Sciences, Bakkannapalem, Visakhapatnam, Andhra Pradesh – 530048, India.

K. Sai Deekshita

Visakha Academy of Physiomedical Sciences, Bakkannapalem, Visakhapatnam, Andhra Pradesh – 530048, India.

M. Rajani Cartor

Visakha Academy of Physiomedical Sciences, Bakkannapalem, Visakhapatnam, Andhra Pradesh – 530048, India.

*Author to whom correspondence should be addressed.


Abstract

Background: COVID-19 frequently impairs pulmonary function during the post-recovery phase. Assessing respiratory status using accessible, equipment-free methods such as Single Breath Count (SBC) and Peak Expiratory Flow Rate (PEFR) is valuable for monitoring long-term functional recovery.

Objectives: To evaluate the correlation between PEFR and SBC, determine their test–retest reliability, and assess whether PEFR can predict SBC performance in individuals with post-COVID-19 sequelae.

Materials and Methods: This observational study evaluated 60 patients with post-COVID-19 sequelae (aged 20–50 years) selected through convenience sampling. PEFR was recorded using a Mini-Wright peak flow meter, and SBC was evaluated using a standardised breath-counting protocol. Pearson’s correlation coefficient was used to determine the relationship between the measures. Intraclass correlation coefficients (ICCs) assessed test–retest reliability, while linear regression and k-fold cross-validation evaluated predictive validity and model stability.

Results: A statistically significant weak-to-moderate positive correlation was observed between PEFR and SBC (r = 0.338, p = 0.008). Both measures demonstrated high test–retest reliability, with ICC values of 0.89 for PEFR and 0.86 for SBC. Linear regression showed that PEFR was a weak predictor of SBC (R² = 0.11, p = 0.037), a finding supported by k-fold cross-validation (mean r = 0.34 ± 0.30).

Conclusion: SBC was significantly correlated with PEFR, indicating that the two measures reflect complementary dimensions of post-COVID respiratory impairment. Given their high test–retest reliability, integrating the equipment-free SBC into physiotherapy practice may provide a practical, low-cost option for remote monitoring and telerehabilitation.

Keywords: Post-COVID-19 sequelae, peak expiratory flow rate, single breath count, pulmonary function, respiratory assessment, test–retest reliability, physiotherapy, telerehabilitation


How to Cite

Sarmila, D., N. Rama Tulasi, K. Sai Deekshita, and M. Rajani Cartor. 2026. “Correlation Between Peak Expiratory Flow Rate and Single Breath Count in Patients With Post-COVID Sequelae: An Observational Study”. Journal of Pharmaceutical Research International 38 (9):50-56. https://doi.org/10.9734/jpri/2026/v38i97871.

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