Journal of Pharmaceutical Research International

Guduchyadi Medhya Rasayana herb is an Ayurvedic formulation herb that is useful to improve memory. It is utilized for the stress management and improvement of cognitive health in children, advocating for the standardization of the intervention for clinical application in stress reduction among pediatric patients as well as general mental. The formulation is composed of eight herbal ingredients: Guduchi (Tinospora cordifolia), Apamarga (Achyranthes aspera), Shankhpushpi (Convolvulus pluricaulis), Vacha (Acorus calamus), Haritaki (Terminalia chebula), Shatavari (Asparagus racemosus), Vayvihdanga (Embelia ribes), and Kushtha (Saussurea lappa). This study investigates and validates the pharmacognostic and analytical properties of Guduchyadi Rasayana, with a specific focus on its efficacy in stress reduction for children. Prepared in compliance with Good Manufacturing Practices (GMP), the formulation underwent various analyses, including organoleptic, physicochemical, and thin-layer chromatography (TLC). Organoleptic testing revealed a greenish-yellow color and a pleasant fragrance. Physicochemical results indicated an alcohol-soluble extractive value of 29.94%, total ash content of 9.54%, and water-soluble extractive of 22.07%. TLC fingerprinting provided distinct Rf values (0.48, 0.51, 0.73, 0.83, 0.90), identifying several active phytochemicals that may contribute to its stress-relieving effects. The study’s findings confirm that a broad spectrum of active ingredients in Guduchyadi Rasayana supports its standardization for clinical use. However, any clinical study can assess its efficacy in pediatric stress reduction and overall mental well-being.