Evaluation of the Anti-pyretic Effects of Ethanolic Extract of Sonchus wightianus DC Using Wistar Rats
Dhawal Pal *
Swami Vivekanand College of Pharmacy, Indore (M. P.), India.
Anant Kumar Patel
Swami Vivekanand College of Pharmacy, Indore (M. P.), India.
Sohan Singh Chouhan
Swami Vivekanand College of Pharmacy, Indore (M. P.), India.
*Author to whom correspondence should be addressed.
Abstract
This study aimed to investigate the ethanolic extract of Sonchus wightianus DC for its pharmacological activities, including anti-pyretic, behavioral, and immunomodulatory effects. The extract was prepared via Soxhlet extraction, and its chemical composition was analyzed for bioactive compounds. The extract demonstrated significant antipyretic effects in both yeast-induced and vaccine-induced hyperpyrexia models in rats. Furthermore, behavioral tests revealed an increase in ambulation and rearing frequency compared to the negative control group. Additionally, a notable reduction in white blood cell (WBC) count was observed, suggesting potential immunomodulatory properties. These results support the medicinal potential of Sonchus wightianus DC in treating fever and modulating immune responses.
Keywords: Sonchus wightianus DC, ethanolic extract, anti-pyretic, behavioral effects, immune modulation, Soxhlet extraction, phytochemical analysis