Phytochemical Study, Evaluation of Antihelminthic Potential and In silico Screening for Breast Cancer Using Mimosa pudica Linn.

Aravinth Velmurugan *

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry- 607402, India.

Keerthana Chandramohan

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry- 607402, India.

Ganeshan Thamizhselvan

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry- 607402, India.

Yogesh Shokkalingam

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry- 607402, India.

Venkatesan Natarajan

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry- 607402, India.

Pradeepraj Devarasu

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry- 607402, India.

Thamizh Sendhamaraikannan

School of Pharmacy, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry- 607402, India.

*Author to whom correspondence should be addressed.


Abstract

Breast Cancer is a major health concern in India, where it is highly lethal for women because of unchecked cell proliferation and metastasis, which are frequently caused by interactions between the Estrogen Receptor Alpha and other receptors. Even though they work well, synthetic Anthelmintics come with dangers to the health of both humans and animals. Therefore, creating effective and safe Anthelmintics from plant sources is our main goal. We extracted Mimosa pudica leaves with ethanol using a Soxhlet system, and after concentration, we examined the extract using GC-MS, FTIR, and UV techniques. Estrogen Receptor structure and flavonoid compound databases from PubChem and Protein Data Bank were used for in silico testing against Breast Cancer and anthelmintic action, respectively.  Using molecular docking and drug similarity investigations, the effectiveness of natural compounds against Breast Cancer was evaluated.

Keywords: Breast cancer, estrogen receptor alpha, anthelmintics, mimosa pudica leaves, soxhlet extraction, GC-MS, FTIR, UV analysis


How to Cite

Velmurugan , A., Chandramohan , K., Thamizhselvan , G., Shokkalingam , Y., Natarajan , V., Devarasu , P. and Sendhamaraikannan , T. (2024) “ Evaluation of Antihelminthic Potential and In silico Screening for Breast Cancer Using Mimosa pudica Linn”., Journal of Pharmaceutical Research International, 36(6), pp. 135–143. doi: 10.9734/jpri/2024/v36i67529.

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