Role of Ayurvedic Herbs in the Management of Celiac Disease

Gayatri *

P. G. Department of Bal Roga (Ayurveda Pediatrics), Postgraduate Institute of Ayurveda, Dr. S. R. Rajasthan Ayurved University, Jodhpur, Rajasthan, India.

Jigyasha

P. G. Department of Bal Roga (Ayurveda Pediatrics), Postgraduate Institute of Ayurveda, Dr. S. R. Rajasthan Ayurved University, Jodhpur, Rajasthan, India.

Harish Kumar Singhal

P. G. Department of Bal Roga (Ayurveda Pediatrics), Postgraduate Institute of Ayurveda, Dr. S. R. Rajasthan Ayurved University, Jodhpur, Rajasthan, India.

*Author to whom correspondence should be addressed.


Abstract

Celiac disease or gluten-sensitive enteropathy is an autoimmune hypersensitivity disorder affecting the small intestine. It occurs due to an inappropriate immune reaction to gluten, which results in inflammation and damage to the small intestine. One of the most prevalent illnesses, celiac disease, is brought on by both environmental (gluten) and genetic causes of human leukocyte antigen (HLA) and non-HLA genes. The prevalence of celiac disease has been estimated to approximate 0.5%-1% in different parts of the world. Due to improved physician awareness and expertise, as well as the widespread use of extremely sensitive and precise diagnostic tests for celiac disease, the prevalence of celiac disease has considerably grown in the past 30 years. While older children have either limited or unusual symptoms, only a small percentage of celiac patients have the classic signs of the condition like chronic or intermittent diarrhea, failure to thrive, weight loss, delayed puberty, short stature, nausea, vomiting, chronic abdominal pain, abdominal distension, chronic constipation. Early detection of celiac disease is crucial to preventing long-term consequences. According to Ayurveda, some symptoms of celiac disease found in  Grahani Dosha. Grahani is described as an Agni Adhisthana by most of Acharya. Mandagini is the root cause of Ama Dosha, and it is a crucial factor for the manifestation of most diseases. The treatment approach of celiac disease in Ayurveda medicinal science involves the intake of various preparations of some specific medicinal plants like Kutaja (Holarrhena antidysenterica) Pippali, (Piper longum Linn.), Chitraka, (Plumbago zeylanica) Guduchi, (Tinospora cordifolia) Ashwagandha, (Withania somnifera), Haridra (Curcuma longa Linn.), etc which have Agni Deepana and Ama Pachana properties. These illness-specific medicinal herbs help normalize digestive fire and evict "Ama" toxins from the body channels, which pacify the vitiated Agni and maintain homeostasis among vitiated Doshas.

Keywords: Ayurvedic herbs, ashwagandha, celiac disease, chitraka, grahani dosha, grani roga, guduchi, haridra and kutaja


How to Cite

Gayatri, Jigyasha and Singhal , H. K. (2024) “Role of Ayurvedic Herbs in the Management of Celiac Disease”, Journal of Pharmaceutical Research International, 36(6), pp. 122–134. doi: 10.9734/jpri/2024/v36i67528.

Downloads

Download data is not yet available.

References

Husby S, Koletzko S, Korponay-Szabó I, Kurppa K, Mearin ML, Ribes-Koninckx C, Shamir R, Troncone R, Auricchio R, Castillejo G, Christensen R, Dolinsek J, Gillett P, Hróbjartsson A, Koltai T, Maki M, Nielsen SM, Popp A, Størdal K, Werkstetter K, Wessels M. European society paediatric gastroenterology, hepatology and nutrition guidelines for diagnosing coeliac disease. Journal of Pediatric Gastroenterology and Nutrition. 2020;70(1):141–156. Available:https://doi.org/10.1097/MPG.0000000000002497 [PubMed]

Fasano A, Catassi C. Clinical practice. Celiac disease. The New England Journal of Medicine. 2012;367(25):2419–2426. Available:https://doi.org/10.1056/NEJMcp1113994 [PubMed]

Robert M Kliegman, Joseph St. Nelson text Book of Pediatrics, 21st Edition, volume 2, Geme Philadephia, Elsevier1991; 2020.

Tye-Din JA, Galipeau HJ, Agardh D. Celiac disease: A review of current concepts in pathogenesis, prevention, and novel therapies. Frontiers in Pediatrics. 2018;6:350. Available:https://doi.org/10.3389/fped.2018.00350

Savvateeva LV, Erdes SI, Antishin AS, Zamyatnin AA, Jr. Current paediatric coeliac disease screening strategies and relevance of questionnaire survey. International Archives of Allergy and Immunology. 2018;177(4):370–380. Available:https://doi.org/10.1159/000491496 [PubMed]

McAllister BP, Williams E, Clarke K. A comprehensive review of celiac disease/gluten-sensitive enteropathies. Clinical Reviews in Allergy and Immunology. 2019;57(2):226–243. Available:https://doi.org/10.1007/s12016-018-8691-2 [PubMed]

Devlin SM, Andrews CN, Beck PL. Celiac disease. CME update for family physicians. Canadian family physician Medecin de famille canadien. 2004;50:719–725.

Bai JC, Ciacci C. World gastroenterology organisation global guidelines: Celiac disease February 2017. Journal of Clinical Gastroenterology. 2017;51(9):755–768. Available:https://doi.org/10.1097/MCG.0000000000000919

Walker MM, Ludvigsson JF, Sanders DS. Coeliac disease: Review of diagnosis and management. The Medical Journal of Australia. 2017;207(4):173–178. Available:https://doi.org/10.5694/mja16.00788. [PubMed]

Do Vale RR, Conci NDS, Santana AP, Pereira MB, Menezes NYH, Takayasu V, Laborda LS, Da Silva ASF. Celiac crisis: An unusual presentation of gluten-sensitive enteropathy. Autopsy and Case Reports. 2018;8(3):e2018027. Available:https://doi.org/10.4322/acr.2018.027.[PubMed]

Yadavji T. Charak Samhita on Ayurved Dipika commentary by Agnivesh, published by Chowkhamba Krishnadas Academy, Varanasi, edition- reprint, Chikitsa Sthana, Chapter. 2015;15:517.

Yadavji T. Sushruta Samhita on Nibandha Sangraha commentary by Dalhan, Published by Chaukhamba Sanskrit Sansthan, Varanasi, Edition Reprint Uttar tantra, Chapter. 2012;40:709.

Swami D, Gharote ML. Copyright by: Kaivalyadhama SMYM, Samiti, Lonavla (Maharashtra-India) – 410- 403 First published Mahashivaratri, 7th 1 March 1978 Second Edition April 1997); 1978.

Pt. Shastri HSP. Ashtanga Hridayam ,with sarvangasundara and Ayurved Rasayana Commentry by Arundutta and Hemadri respectively .Nidanasathana, Atisaragrahani Adhyaya 89 , Chaukhamba Surbharati Prakashana;, Varanasi. 2002;498-499.

Muktibodhanand S. Hatha yoga Pradipika-a light on hatha yoga, Yoga Publications Trust,

Munger, Bihar India; 2002.

Jain, Sapan, Chawardol, Seema, Jain, Jinesh, Dwivedi OP. Management of Grahani roga by ayurveda principles and life style modification. Journal of Drug Delivery and Therapeutics. 2018;8:393-396. DOI: 10.22270/jddt.v8i6.2061

Yadav, Parag. Medical perspective on ama as per ayurveda and modern consideration: A review. Journal of Drug Delivery and Therapeutics. 2020;10:205-207. DOI: 10.22270/jddt.v10i1-s.3861

Chunekar KC. Bhavaprakasha Nighantu (Indian materia medica); Chaukhambha Bharati Academy, Varanasi. Reprint. 2018;257-465.

Kumar A, Ali M. A new steroidal alkaloid from the seeds of Holarrhena antidysenterica. Fitoterapia. 2000;71(2):101–104. Available:https://doi.org/10.1016/s0367-326x(99)00111-2

Yang ZD, Duan DZ, Xue WW, Yao XJ, Li S. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships. Life Sciences. 2012;90(23-24):929–933. Available:https://doi.org/10.1016/j.lfs.2012.04.017

Ganapathy, Sujan, Ramachandra Y L, Rai, Padmalatha. Antiinflammatory and analgesic activities of Holarrhena antidysenterica Wall. Leaf extract in Experimental Animal Models. 2011;4:101-103.

Shwetha C, Latha KP, Asha K. Study on analgesic activity of Holarrhena antidysenterica leaves. International Journal of Herbal Medicine. Anti-diarrhoeal activity. 2014;2(3):14-1.

Sharma DK, Gupta VK, Kumar S. Evaluation of antidiarrheal activity of ethanolic extract of Holarrhena antidysenterica seeds in rats. Veterinary World. 2015;8(4):1392-1395.

Kunal, Gupta, Karale, Sanjiv, Vijayanand, Warad. Anti diarrhoeal activity of a polyherbal formulation in various animal models diarrhoea. International Research Journal of Pharmacy. 2012;3:289-290.

Chunekar KC. Bhavaprakash Nighantu, 6th edition, Chaukhambha Bharat Academy, Varanasi. 1982;15.

Kumari, Mamta, Bk, Ashok, Ravishankar, Basavaiah, Pandya, Tarulata, Acharya, Rabinarayan. Antiinflammatory activity of two varieties of Pippali (Piper longum Linn.). Ayu. 2012;33:307-10. DOI: 10.4103/0974-8520.105258

Database on Medicinal Plants Used in Ayurveda, by PC Sharma, MB Yelne, Dennis TJ. Central Council For Research In Ayurveda & Siddha, Reprint Janakpuri, New Delhi, Part I, 2005;2(3):472.

Sharma A, Singh R. Screening of antiinflammatory activity of certain indigenous drugs on carrageenin induced hind paw edema in rats, Bull. Med. Ethnobot. Res. 1980;2:262.

Kumar S, Arya P, Mukherjee C, Singh BK, Singh N, Parmar VS. Novel aromatic ester from Piper longum and its analogues inhibit expression of cell adhesion molecules on endothelial cells. Biochemistry. 2005;6;44:15944−52.

Choudhary GP. Mast cell stabilizing activity of piper longum Linn. Indian J Allergy Asthma Immunol 2006;20:112−6.

Stöhr JR, Xiao PG, Bauer R. Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis In vitro. Journal of Ethnopharmacology. 2001;75(2-3):133–139. Available:https://doi.org/10.1016/s0378-8741(00)00397-4

Natarajan KS, Narasimhan M, Radha SK, Shanmugasundaram ERB. Antioxidant activity of a salt-spice-herbal mixture against free radical induction. Journal of Ethnopharmacology. 2006;105:76-83. Available:https://doi.org/10.1016/j.jep.2005.09.043

Vedhanayaki G, Shastri GV, Kuruvilla A. Analgesic activity of Piper longum Linn. root. Indian Journal of Experimental Biology. 2003;41(6):649–651.

Bajad S, Bedi KL, Singla AK, Johri RK. Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med. 2001;67(2):176-179. DOI: 10.1055/s-2001-11505

Dhanush SS, Lakshmi SP, Prakash L. Hegde. A review of vrushya dravyas of guduchyadi varga of bhavaprakasha nighantu. J Ayurveda Integr Med Sci. 2021;3:46-49.

The Ayurvedic Pharmacopoeia of India, Part-I, Volume- I, Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga, Naturopathy, Unani, Siddha and Homeopathy, New Delhi. Available:http://www.ayurveda.hu/api/API-Vol-1.pdf

Bafna PA, Balaraman R. Anti-ulcer and antioxidant activity of pepticare, a herbomineral formulation. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2005;12(4):264–270. Available:https://doi.org/10.1016/j.phymed.2003.12.009[Pub Med]

Mohan H. Textbook of Pathology. 5th ed., New Delhi: Jaypee Brothers Medical Publisher (P) Ltd. 2010;6:133.

Patgiri B, Umretia B, Vaishnav P, Prajapati P, Shukla V, Ravishankar B. Antiinflammatory activity of Guduchi Ghana (aqueous extract of Tinospora cordifolia Miers.). AYU (An International Quarterly Journal of Research in Ayurveda), 2014;35(1):108. Available:https://doi.org/10.4103/0974-8520.141958.

Antonisamy P, Dhanasekaran M, Ignacimuthu S, Duraipandiyan V,Balthazar JD, Agastian P, et al. Gastroprotective effect of epoxyclerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats. Phytomedicine. 2014;21(7):966-969. DOI: 10.1016/j.phymed.2014.02.010

Sarma DNK, Khosa RL, Chansauria JPN, Sahai M. Antiulcer activity of Tinospora cordfolia miers and Centella asiatica Linn extracts. Phytother Res 1995;9: 589-90.

Alexander CP, Kirubakaran CJ, Michael RD. Water soluble fraction of Tinospora cordifolia leaves enhanced the non-specific immune mechanisms and disease resistance in Oreochromis mossambicus. Fish Shellfish Immunol. 2010;29(5):765-772. DOI: 10.1016/j.fsi.2010.07.003

Sharma PV. Dravya GunaVigyana, Chaukhambha Bharati Academy, Varanasi, Reprint. 2003;(2).

Kulkarni SK, Dhir A. Withania somnifera: An Indian ginseng. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2008;32(5):1093–1105. Available:https://doi.org/10.1016/j.pnpbp.2007.09.011

Saleem, S., Muhammad, G., Hussain, M. A., Altaf, M., & Bukhari, S. N. A. (2020). Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. Iranian journal of basic medical sciences, 23(12), 1501–1526. https://doi.org/10.22038/IJBMS.2020.44254.10378

Kanji lal S., Gupta A.K., Patnaik R.S., Dey A. Analysis of Clinical Trial Registry of India for Evidence of Anti-Arthritic Properties of Withania somnifera (Ashwagandha) Altern. Ther. Health Med. 2021;27:58–66. [PubMed] [Google Scholar]

Dar NJ, Hamid A, Ahmad M. Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cellular and molecular life sciences: C.M.L.S. 2015;72(23):4445–4460. Available:https://doi.org/10.1007/s00018-015-2012-1

Davis L, Kuttan G. Immunomodulatory activity of Withania somnifera. Journal of Ethnopharmacology. 2000;71(1-2):193–200. Available:https://doi.org/10.1016/s0378-8741(99)00206-8

Mandlik Ingawale DS, Namdeo AG. Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements. 2021;18(2):183–226. Available:https://doi.org/10.1080/19390211.2020.1741484

Rawat, Neha, Roushan, Rakesh. Ashwagandha (Withania Somnifera): A potential aphrodisiac drug in Ayurveda. 2019;8:1034-1041.

Bhavamishra. Bhavaprakasha Nighantu Commentary by Chunekar Krishnachandra, Edited by Pandey Gangasahaya, Chaukambha Bharati Academy, Varanasi, Reprint; 1999.

Shukla B, Saxena S, Usmani S, et al. Phytochemistry and pharmacological studies of Plumbago zeylanica L.: A medicinal plant review. Clin Phytosci. 2021;7:34. Available:https://doi.org/10.1186/s40816-021-00271-7

Sheeja E, Joshi SB, Jain DC. Bioassay-guided isolation of antiinflammatory and antinociceptive compound from Plumbago zeylanica leaf. Pharm Biol. 2010;48(4):381–7. Available:https://doi.org/10.3109/13880200903156424

Subramaniyan V, Paramasivam V. Potential antiinflammatory activity of Plumbago zeylanica. Asian J Pharm Clin Res. 2017;10(10):372–5. Available:https://doi.org /10.22159 /ajpcr.2017 .v10i10.20357

Falang KD, Uguru MO, Wannang NN, Azi IH, Chiamaka N. Antiulcer activity of Plumbago zeylanica Linn root extract. J Nut Prod Plant Resour. 2012;2(5): 563–7.

Kodati, Devender, Burra, Shashidher, Kumar P. Evaluation of wound healing activity of methanolic root extract of Plumbago zeylanica L. in Wistar albino rats. Asian Journal of Plant Science and Research. 2011;1:26-34.

Choudhary, Shailja, Kaurav, Hemlata, Chaudhary, Gitika. Chitraka (Plumbago zeylanica): A Potential Rejuvenator. International Journal for Research in Applied Sciences and Biotechnology. 2021;8:202-212. DOI: 10.31033/ijrasb.8.2.26

Bhavmisra Bhavaprakasha Nighantu (edited by Dr. G.S. Pandey, commentary by Dr. K.C. Chunekar), Haritakyadi Varga/197, reprint, published by Chaukhambha Bharti Academy, Varanasi. 2009;114.

Scazzocchio B, Minghetti L, D'Archivio M. Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin. Nutrients. 2020;12(9):2499. Available:https://doi.org/10.3390/nu12092499

SAHA, HPL. Pharmacological activities of wild turmeric (Curcuma aromatic Salisb): A review. J.Pharmacogn. Phytochem; 2015.

Duggi, Shrishail, Handral, Harish, Handral, Ravichandra G, Tulsianand SD, Shruthi. Turmeric: Nature's precious medicine. Asian Journal of Pharmaceutical and Clinical Research. 2013;6:10-16.

Rao CV. Regulation of COX and L.O.X. by curcumin. Advances in Experimental Medicine and Biology. 2007;595:213–226. Available:https://doi.org/10.1007/978-0-387-46401-5_9

Gopinath G, Margesan M, Thirumal, Kumar P. Holarrhena antidysenterica Linn. – A Review. Research Journal of Pharmacy and Technology. 2020;13:2013. DOI: 10.5958/0974-360X.2020.00362.5.

Warrier PK, Nambiar VP, Raman KC. Vol. 4. Madras, India: Orient Longman Ltd; Piper longum, Indian Medicinal Plants. 1995;290. [Google Scholar]

Mulker VG, Ghotankar AM. Therapeutic uses of chitraka (Plumbago Zeylanica Linn.) With a Note On It's Pharmacological Actions. -A REVIEW, WJPMR. 2020;6(4):56-59.

Rawat, Neha, Roushan, Rakesh. Guduchi; A Potential Drug In Ayurveda. 2018;7:355-361. DOI: 10.20959/wjpr201812-12674

Khanchandani, Nisha, Shah, Prachi, Kalwani, Twinkle, Ardeshna, Anujkumar, Dharajiya, Darshan. Antibacterial and Antifungal Activity of Ashwagandha (Withania somnifera L.): A Review. 2019;9:154-161. DOI: 10.22270/jddt.v9i5-s.3573

Chakraborty S, Das A. A Classical Ayurveda Review on Haridra. Ayushdhara. 2020;7(Supply1):47-55. Available:https://doi.org/10.47070/ayushdhara.v7iSupply1.579