A Comparison and Evaluation of Loop Diuretic Frusemide Generic vs Brand Tablets

Tamilveeran T

Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, 608002, India.

Karthikeyan B

School of Pharmacy, Sri Balaji Vidyapeeth, SBV Campus, Pillaiyarkuppam, Pondicherry, 607402, India.

Balamurugan K. *

Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, 608002, India.

*Author to whom correspondence should be addressed.


Abstract

Branded medications are the original products developed by pharmaceutical companies and generic drugs are copies of branded drugs whose patent has expired. The research work focused on comparisons and evaluations of generic VS brand of frusemide tablets. The study includes some of the specifications that should tested in the finished products in tablets such as appearance, thickness, diameter, weight variation, hardness, friability, disintegration time,  dissolution, hardness and thickness as per pharmacopoeial & non pharmacopoeial tests were performed. The generic and brand frusemide tablets quality control results showed within the range as per IP. The in vitrodrug release of generic frusemide tablets was found to be 96.7 %in 45 min and branded tablets which showed drug release 98.3% in 45 min. Hence, it can be concluded that evaluation of loop diuretic frusemide tablets generic and brand frusemide tablets showed same deviations in the quality control results as per IP. 

Keywords: Frusemide, generic, brand, quality control test


How to Cite

T, T., B, K. and K. , B. (2024) “A Comparison and Evaluation of Loop Diuretic Frusemide Generic vs Brand Tablets”, Journal of Pharmaceutical Research International, 36(4), pp. 24–32. doi: 10.9734/jpri/2024/v36i47509.

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References

Petrova E. Innovation in the pharmaceutical industry: The process of drug discovery and development. InInnovation and Marketing in the Pharmaceutical Industry: Emerging Practices, Research, and Policies 2013 Oct 26 New York, NY: Springer New York. 2013;19-81.

Allen L, Ansel HC. Ansel's pharmaceutical dosage forms and drug delivery systems. Lippincott Williams & Wilkins; 2013.

Rägo L, Santoso B. Drug regulation: history, present and future. Drug benefits and risks: International Textbook of Clinical Pharmacology. 2008;2:65-77.

Ashlesha G, Atakale M, Shinde A, Yedge V. Generic drugs vs branded drugs: view of public. Current Trends in Pharmacy and Pharmaceutical Chemistry. 2020;2(2):33-8.

Singal GL, Nanda A, Kotwani A. A comparative evaluation of price and quality of some branded versus branded–generic medicines of the same manufacturer in India. Indian Journal of Pharmacology. 2011;43(2):131.

Colgan S, Faasse K, Martin LR, Stephens MH, Grey A, Petrie KJ. Perceptions of generic medication in the general population, doctors and pharmacists: A systematic review. BMJ Open. 2015;5(12): e008915.

Khan AN, Khar RK, Udayabanu M. Pilot study of quality of diclofenac generic products using validated in-house method: Indian drug regulatory concern. Journal of Applied Pharmaceutical Science. 2015;5(12):147-53.7) Greene JA. Generic: The unbranding of modern medicine. JHU Press; 2014.

Sweetman SC editors. Martindale, ‘The Complete Drug Reference. 36th Edition. London: Pharmaceutical Press. 2009: 1292.

Shankar SS, Brater DC. Loop diuretics: from the Na-K-2Cl transporter to clinical use. American Journal of Physiology-Renal Physiology. 2003;284(1): F11-21.

Azlan NF, Koeners MP, Zhang J. Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension. Acta Pharmaceutica Sinica B. 2021;11(5):1117-28.

Burton RF. Ionic regulation and water balance. The Mollusca-Physiology. 1983: 293-350.

Sappani HK, Karthikeyan S. 4-Chloro-2-((furan-2-ylmethyl) amino)-5-sulfamoylbenzoic Acid (FSM) and N-(Isopropylcarbamoyl)-4-(m-tolylamino) Pyridine-3-sulfonamide (TSM) as Potential Inhibitors for Mild Steel Corrosion in 1 N H2SO4 Medium. Part I. Industrial & Engineering Chemistry Research. 2014;53 (9):3415-25.

Brater DC, Ellison DH, Emmett M. Causes and treatment of refractory edema in adults. Up to date; 2022.

Indian Pharmacopoeia. 8th edition. 2018; 299-309 & 2135-2136).

Elghnimi T, Benamer W, Walli R, Benshaban M, Benashour M. Comparative in-vitro Evaluation of Some Desloratadine Tablets Marketed in Tripoli Libya. AlQalam Journal of Medical and Applied Sciences. 2022:556-64.

United State Pharmacopoeia27/ National Formulary 22. Asian Edn., United state Pharmacopeial Convention Inc., Rockville. 2004;2622.