Formulation and in vitro Evaluation of a Novel Gastroretentive Gas-Generating Floating Matrix Tablets of Domperidone
Muhammad Abid Mustafa *
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Seerat Shahzad
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Zuha Tariq
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Obeda Asghar
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Umar Ali
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Rabia Zaka
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Muhammad Suffyan
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Muhammad Junaid Yaqoob
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Rimsha Riaz
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Kaif Ali
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Umair Ahmed
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Aneeza Safdar
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Muhammad Aamir
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
Muhammad Zahid Iqbal
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Aim and Objective: Domperidone floating matrix tablets were developed to increase the drug's bioavailability by prolonging its stomach residence time. These systems aim to provide controlled release, enhanced bioavailability, and improved patient compliance compared to conventional systems, especially for drugs with prolonged gastric residence.
Methodology: The wet granulation method was employed in formulating the tablets, utilizing polymers such as carboxymethylcellulose and carbopol. Various physical attributes of the tablets, including hardness, thickness, friability, weight variation, FTIR, XRD, drug content, and floating properties, were evaluated. Furthermore, the 12-hour in vitro drug release properties of the tablets were examined.
Results: As the tablets floated in the dissolving medium, they exhibited extended and sustained drug release characteristics. It was established that the drug release mechanism from these tablets followed Fickian diffusion, highlighting the crucial roles played by polymer rearrangement and water diffusion in the process of drug release. The choice of the optimal formulation (F3) was based on its in vitro characteristics.
Conclusion: The investigations conducted affirmed that the tablets are poised to deliver the intended therapeutic effects while maintaining an optimal residence time in the stomach, coupled with prolonged drug release.
Keywords: Floating time, gastric emptying time, CMC, anti-emetic, prolong release