Evaluation of Potential Drug-drug Interactions in Prescription in Outpatient Department of Tertiary Care Hospital
Sunil M. Mahakalkar
Department of Pharmacology, GMCH, Nagpur, India.
Akhil Giradkar
Department of Pharmacology, GMCH, Nagpur, India.
Rahul Gholse
Department of Pharmacology, GMCH, Nagpur, India.
Umesh Rathod *
Department of Pharmacology, GMCH, Nagpur, India.
Divya Raj
Department of Pharmacology, GMCH, Nagpur, India.
*Author to whom correspondence should be addressed.
Abstract
Aims: To evaluate potential drug- drug interactions (pDDIs) in prescriptions generated in outpatient department.
Study Design: A cross sectional, observational study.
Place and Duration of Study: Pharmacy store, Government Medical College & Hospital, Nagpur, between July 2022 to September 2022.
Methodology: Cross Sectional study performed in outpatient department from July 2022 to September 2022 analysed 382 patient prescriptions (Male : Female 1.41 : 1.0 ; Mean Age 33.67 ± 23.18 ) to evaluate for potential DDIs. Precription with atleast 2 drugs were included in the analysis. Data was analysed for potential drug- drug interactions using Rx list drug interaction checker Online, an online software to check drug-drug interactions (https://www.rxlist.com/drug-interaction-checker.htm) available on the website. Descriptive statistics were performed using MS Excel 2019.
Results: Of the 382 (Male: Female 1.41 : 1.0 ; Mean Age 33.67 ± 23.18 )prescriptions analysed for potential DDIs , 55 prescription were found to have potential DDIs. In those 55 prescriptions, 73 potential DDIs were identified.
Conclusion: Incidence of potential drug- drug interactions was found to be 14.39% in these study.
Keywords: Potential drug- drug interactions, prescription, Rx list drug interaction checker, Aspirin