Solvent free Synthesis of 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl] Acetohydrazide Derivatives as Novel Antimicrobial and Antitumor Agents

J. Paveendra

Department of Chemistry, Sahyadri Science College, Shivamogga-577203, India.

H. M. Vagdevi *

Sahyadri Science College, Shivamogga-577203, India.

Dyamanna Thippeswamy

Department of Chemistry, School of Chemical Sciences, Kuvempu University, Jnana-Sahyadri, Shankaraghatta-577 451, Karnataka, India.

Yanjerappa Arthobha Nayaka

Department of Chemistry, School of Chemical Sciences, Kuvempu University, Jnana-Sahyadri, Shankaraghatta-577 451, Karnataka, India.

*Author to whom correspondence should be addressed.


In pursuit of designing novel chemical entities with antitumor and antimicrobial activities, 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl]acetohydrazidederivatives have been synthesized as a scaffold of a series of amine derivatives, these analogs were on reductive amination with solvent free condition. All the synthesized compounds were assessed for antibacterial, antifungal, and antitumor activities against standard strains. The compounds 3a, 3b and 3g showed highest degree of inhibition against A. flavus and compounds 3a, 3b, 3d and 3h Showed highest degree of inhibition against C. albicans, compounds 3a,3e and 3g has shown the encouraging antibacterial activityresults against E. coli and compounds 3a, 3b and 3h exhibited a promising activity against  B. subtilis. Compounds 3a, 3b and 3c exhibited promising antitumor activity.

Keywords: Benzoxazole, solvent free condition, antitumor, antimicrobial

How to Cite

Paveendra , J., Vagdevi , H. M., Thippeswamy, D. and Nayaka , Y. A. (2023) “Solvent free Synthesis of 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl] Acetohydrazide Derivatives as Novel Antimicrobial and Antitumor Agents”, Journal of Pharmaceutical Research International, 35(13), pp. 36–45. doi: 10.9734/jpri/2023/v35i137368.


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