The Wound Healing Potential of 2,3 Dimethylquinoxaline Hydrogel in Rat Excisional Wound Model
Abdelbagi Elfadil *
Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, KSA and Center of Research Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, KSA.
Ahmed S. Ali
Department of clinical pharmacology, Faculty of Medicine, King Abdulaziz University, KSA.
Mohammad W. Alrabia
Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, KSA.
Hamoud Alsamhan
Department of Pharmacy Practice, College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, KSA and Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, KSA.
Hind Abdulmajed
Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, KSA.
Ibrahim Ismail Mohammed Abu
Department of Community Medicine, Faculty of Medicine, King Abdulaziz University, KSA.
Mohammad Allibaih
Examination and Assessment Unit, Faculty of Medicine, King Abdulaziz University, KSA.
Khalid Hussein Bakheit Ahmed
Clinical Biochemistry department, Faculty of Medicine, King Abdulaziz University, KSA.
*Author to whom correspondence should be addressed.
Abstract
Background: 2,3-dimethylquinoxaline (DMQ) is a naturally occurring compound with documented antifungal activity. It showed also good in vitro physicochemical and pharmacokinetic characteristics.
Methods: The wound healing activity of 1% DMQ hydrogel in healthy adult male Wister rats were evaluated using the excision wound model. On day 7, the mean percentage closure of the wound area was determined. The animals were sacrificed on day 7 and skin was isolated for histology research and assessment of some inflammatory & oxidative markers, hydroxyproline and tissue growth factor.
Results and Discussion: Almost complete wound healing was observed after treatment with DMQ 1 % Jell for 7 days. The histological study confirmed marked attenuation of wound-induced histological changes. There was a marked reduction in TNF-α, IL-6 IL-β1 and NF-κB. levels. These data suggest the potential anti-inflammatory effect of DMQ.
Conclusion: DMQ has potential skin wound healing ability likely due to its anti-inflammatory mechanism. Further study is needed to confirm these preliminary findings and explore the molecular mechanism
Keywords: 2,3-dimethylquinoxaline, hydrogel, wound healing, inflammatory biomarkers