Pharmacognostic Screening and Antimalaria Activity of Methanol Bark Extract of Daniellia oliveri (ROLFE) Hutch. & Dalz. [Fabaceae] Extract on Plasmodium berghei Infected Mice
Journal of Pharmaceutical Research International, Volume 35, Issue 4,
Page 9-31
DOI:
10.9734/jpri/2023/v35i47320
Abstract
Introduction: Malaria parasite infection has remained a global leading cause of death and disability in which about 50% of the world population is estimated to be at risk, especially in low and middle income countries.
Aim: This research is designed to evaluate the pharmacognostic, phytochemical profile, and investigate its antimalarial activity by analysing different hematological indices of the methanolic bark extract of Daniellia oliveri, a plant belonging to the family of fabaceae.
Methods: The barks of this plants were collected, cleared, dried, pulverized and sequentially extracted with petroleum ether, n-hexane, ethyl acetate, methanol and aqueous using the soxhlet extractor. Acute toxicity studies (LD50) for the methanol bark extract was studied using standard method. Phytochemical and pharmacognostic screening was carried out using standard methods, its hematological analysis were investigated using standard methods. The antimalarial activity of the methanol bark extract Daniellia oliveri, was evaluated at different doses of 100, 200 and 400mg/kg using in-vivo models.
Results: The plant is a tall slender tree with a dark grey colour. The following extractive values were obtained petroleum ether (0.600±0.10), n-hexane (0.667±0.88), ethyl acetate (1.600±0.10), methanol (8.400±0.10) and aqueous (6.200±0.10).The methanol extract had the hightest extractive value and was found to be non-toxic at dose 5000mg/kg. The qualitative and quantitative phytochemical analyses reveals the presence of alkaloids (10.179±0.61), saponins (1.674±0.43), tannins (10.738±0.61), flavonoids (3.923±0.15), steroids (2.665±0.07), phenols (134.604±14.83), terpenoids (22.436±4.87), glycosides (14.485±0.08), reducing sugars (4.138±1.36), soluble carbohydrates but absence of cyanogenic glycosides The pharmacognostic parameters values were obtained as follows, total ash value (5.600±0.10), acid insoluble ash value (2.800±0.88), water soluble ash value (0.500±0.10), moisture content (13.933±0.12), bitterness value , foaming index (less than 100), swelling index (2.867±0.99).
Conclusion: This result has shown that the hematological analysis carried out exhibited significant improvement in PCV, RBC and Hb when administered the plant extract compared to the standard group. It exhibited significant increase in platelet and lymphocyte while reduction in neutrophil compared to the standard group. The increased hematological indices indicate a better transportation capacity of the red blood cells and this should be attributed to the antimalarial properties of the extract. Also, the white blood differential count indicates a boost in the immune system of the treated P. berghei infected mice. This study justifies the ethno-medicinal use of D. oliveri in the management of malaria.
- Daniellia oliveri
- Plasmodium berghei
- hematological
- artemether
- malaria
- methanolic
How to Cite
References
World Malaria Report. World malaria report 2019. In WHO Regional Office for Africa; 2019. Available: https://www.who.int/news-room/fact-sheets/detail/malaria
Greenwood BM, Bojang K, Whitty CJM, Targett GAT. Malaria. Lancet. 2005; 365(9469):1487–1498. Available: https://doi.org/10.1016/S0140-6736(05)66420-3
Ukaegbu CO, Nnachi AU, Mawak JD, IC. Incidence Of Concurrent Malaria And Typhoid Fever Infections In Febrile Patients In Jos, Plateau State Nigeria. International Journal of Scientific & Technology Research. 2014;3(4):157–161. Available: www.ijstr.org
World Health Organization. Global Malaria Programme. Eliminating malaria. Geneva: World Health Organization. World Health Organization. 2015;243. Available:http://www.who.int/malaria/publications/world-malaria-report-2015/report/en/
Willcox ML, Gilbert B..Traditional herbal medicines for malaria.British Medical Journal. 2004; (329):1156- 1159.
Laxminarayan R. Malaria among African Children. 2006;25–28.
de la Estrella M, Aedo C, Mackinder B, Velayos M. Taxonomic Revision of Daniellia (Leguminosae: Caesalpinio-ideae). Systematic Botany. 2010;35(2): 296-324.
Keay RWJ. Flora of west tropical Africa. Crown Agents for Oversea Governments and Administrations; 1958.
Balogun EA, Adebayo JO. Effect of ethanolic extract of Daniella Oliveri leaves on some cardiovascular indices in rats. Pharmacognosy Magazine. 2007;3(9): 16-20.
Kabore A, Traore A, Tamboura HH, Belem AMG. Anthelminthic activity of Daniellia oliveri against Haemonchus contortus worms in Burkina Faso. International Atomic Energy Agency (IAEA, 2009;41 (14):8-11.
Dassou HG, Ogni CA, Yedomonha H, Adomou AC, Tossou M, Dougnon JT et Akoegninou A. Diversité, usages vétérinaires et vulnérabilité des plantesmédicinales au Nord-Bénin. Int. J. Biol. Chem. Sci. 2014;8(1):189-210
Boye A, Amoateng P, Koffuor GA, Barku VYA, Bawa EM, Anto OE. Anti-nociceptive and antioxidant activity of an aqueous root bark extract of Daniellia oliveri (Rolfe) Hutch.& Dalziel (Fam: Leguminosae [Fabaceae]) in ICR mice. Journal of Applied Pharmaceutical Science. 2013; 3(12):36-45.
Lorke D. A new approach to practical acute toxicity testing. Arch. Toxicol. 1983; 54:275–287. DOI: 10.1007/BF01234480
Brain KR, Tuner TD. The Practical Evaluation of Phytopharmaceuticals. Bristol: Wright Sccintecnica. 1975;81-82, 1975.
Sofowora EA. Medicinal Plants and Traditional Medicine in Africa Spectrum Books Ltd Ibadan; Nigeria. 2008;1-10.
Hassan LG, Dangoggo SM, Umar KJ, Saidu I, Folorunsho FA. Proximate, minerals and anti-nutritional factors of Daniellia oliveri seed kernel. Chem Class J. 2008;5:31-36.
Muanda F, Kon D, Dicko A, Soulimani R, Younos C. Phytochemical composition and antioxidant capacity of three Malian medicinal plant parts. Evidence Based Complementary and Alternative Medicine. 2009;2011(2011):45.
Ahmadu AA, Haruna AK, Garba M, Sule MI, Pateh UU, Ebeshi BU, Sarker SD. Flavonoid glycosides from the leaves of Daniellia oliveri.Nigerian Journal of Natural Products and Medicine, 2004;8(1):67-68.
Alain KY, Valentin WD, Christian KT, Pascal AD, Dominique SC. Phytochemical screening, antibacterial and anti-radical activities of Daniellia oliveri trunk bark extracts used in veterinary medicine against gastrointestinal diseases in Benin. International Journal. 2015;3(10):1190-1198.
Bell D, Winstanley P. Current issues in the treatment of uncomplicated malaria in Africa. Br Med Bull. 2004;71:29-43.
Greenwood BM, Bojang K, Whitty CJM, Targett GAT. Malaria. Lancet. 2005;365 (9469):1487-98.
Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol. 1983;54 (4):275-87.
Trease G, E, Evans W, C. Pharmacognosy. 15th ed. London: Saunders Publishers. 2002;42-4, 221-9, 246-9, 304-6, 331-2, 391-3.
Adama K, Adama B, Tamboura H, Amadou T, Laya S. In vitro anthelmintic effect of two medicinal plants (Anogeissus leiocarpus and Daniellia oliveri) on Haemonchus contortus, an abosomal nematode of sheep in Burkina Faso. Afr J Biotechnol. 2009;8(18):4690-5.
Adoum OA, Micheal BO, Mohammad IS. Phytochemicals and hypoglycaemic effect of methanol stem-bark extract of Ficus sycomorus Linn (Moraceae) on alloxan induced diabetic Wistar albino rats. Afr J Biotechnol. 2012;11(17):4095-7.
Afrane YA, Bonizzoni M, Yan G. Secondary malaria vectors of sub-Saharan Africa: threat to malaria elimination on the continent? Curr Top Malar; 2016.
Ahmadu AA, Agunu A. Phytochemical and biological investigation of Daniellia oliveri leaves (Fabaceae). Planta Med. 2012;78 (11):149-58.
Ahmadu A, Kaita HA, Garba M, Yaro AH. Antispasmodic actions of the leaves of Daniellia oliveri. Niger J Nat Prod Med. 2003;7(1):13-5.
Ahmadu AA, Zezi AU, Yaro AH. Anti-diarrheal activity of the leaf extracts of Daniellia oliveri hutch and Dalz (Fabaceae) and Ficus sycomorus Miq (Moraceae). Afr J Tradit Complement Altern Med. 2007; 4(4):524-8.
Ajibade LT, Fatoba PO, Raheem UA, Odunuga BA. Ethnomedicine and primary healthcare in Ilorin, Nigeria. Indian J Trad Knowl. 2005;4(2):150-8.
Akanbi OM, Omonkhua AA, Cyril-Olutayo CM, Fasimoye RY. The antiplasmodial activity of Anogeissus Leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii. Parasitol Res. 2012;110(1):219-26.
Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S et al. Spread of artemisinin resistance in Plasmodium falciparum Malaria. N Engl J Med. ISSN 1533-4406. 2014;371(5):411-23.
Atolani O, Olatunji GA. Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri. J Pharm Anal. 2014;4(6): 407-11.
Autino B, Noris A, Russo R, Castelli F. Epidemiology of malaria in endemic areas. Mediterr J Hematol Infect Dis. 2012;4(1): e2012060.
Bartoloni A, Zammarchi L. Clinical aspects of f uncomplicated and severe malaria. Mediterr J Hematol Infect Dis. 2012;4(1): e2012026.
Bell D, Go R, Miguel C, Walker J, Cacal L, Saul A. Diagnosis of malaria in a remote area of the Philippines: comparison of techniques and their acceptance by health workers and the community. Bull World Health Organ. 2001;79(10):933-41.
Bell D, Winstanley P. Current issues in the treatment of uncomplicated malaria in Africa. Br Med Bull. 2004;71:29-43.
Brain K, R, Tuner T, D. The practical evaluation of phytopharmaceuticals. Bristol: Wright Sccintecnica. 1975;81-2.
Chineke CA, Ologun AGO, Ikeobi CONI. Haematological parameters in rabbit breeds and crosses in humid tropics. Pak J Biol Sci. 2006;9(11):2102-6.
Chotivanich K, Silamut K, Day NPJ. Laboratory diagnosis of malaria infection – A short review of methods. N Z J Med Lab Sci. 2006;61(1):4-7.
Coker ME, Ogundele OS. Evaluation of the antifungal properties of extracts of Daniella oliveri. Afr J Biomed Res. 2016;19(1):55-60.
Cyril-Olutayo MC, Akanbi OM, Fasimoye R, Omonkhua AA. Effects of Angeissus leiocarpuson hematological parameters of mice infected with Plasmodium berghei. J Plant Stud. 2013;2(2):13-21.
Danlami U, David BM. Physicochemical properties and antioxidant potentials of Daniella oliveri seed oil. Res. J Eng Appl Sci. 2012;1:389-92.
de la Estrella M, Aedo C, Mackinder B, Velayos M. Taxonomic revision of Daniellia (Leguminosae: Caesalpinioideae). Syst Bot. 2010;35(2):296-324.
El-Mahmood AM, Doughari JH, Chanji FJ. In vitro antibacterial activities of crude extracts of Nauclealatifoliaand Daniella oliveri. Sci Res Essays. 2008;3(3):102-5.
Erhart LM, Yingyuen K, Chuanak N, Buathong N, Laoboonchai A, Miller RS et al. Hematological and clinical indices of malaria in a semi-immune population of Western Thailand. Am J Trop Med Hyg. 2004;70(1):8-14.
Ezekwesili CN, Ogbunugafor HA. Blood glucose lowering activity of five Nigerian medicinal plants in alloxan-induced diabetic Wistar albino rats. Anim Res Int. 2015;12(2):2150-8.
Ezenduka CC, Okonta MJ, Esimone CO. Adherence to treatment guidelines for uncomplicated malaria at two public health facilities in Nigeria; Implications for the ‘test and treat’ policy of malaria case management. J Pharm Policy Pract. 2014;7(1):15.
Fleury M. A propos de l'inheret medicinal du baume de Copahu [On medicinal role of Copahubalsan [sic]]. Acta Bot Gallica. 1997;144(4):473-9.
Fitzgerald B, Deal CN, Fitzgerald B, Deal CN. We protect lives; 1950. p. 15-7.
Gilbert M. Medicinal importance of Copaiba oil. J Pharmacol. 2000;4:1159-64.
Gavigan CS, Dalton JP, Bell A. The role of aminopeptidases in hemoglobin degradation in Plasmodium falciparum-infected erythrocytes. Mol Biochem Parasitol. 2001;117(1):37-48.
Houehounha R, Avohou HT, Gaoue OG, Assogbadjo AE, Sinsin B. Weed removal improves coppice growth of Daniellia oliveri and its use as fuelwood in traditional fallows in Benin. Agrofor Syst. 2010;78(2):115-25.
Hubs, R, & excellence, O.F.; 2011 [report].
Hutchinson J, Dalziel JM. Flora of west tropical African. London: Crown Agents. 1963;2.
Igoli JO, Ogaji OG, Tor-Anyiin TA, Igoli NP. Traditional medicine practice amongst the Igede people of Nigeria. Part II. Afr J Trad Compl Alt Med. 2005;2(2).
Isaac LJ, Abah G, Akpan B, Ekaette IU. Haematological properties of different breeds and sexes of rabbits. In: Proceedings of the 18th annual conference of Animal Science Association of Nigeria; 2013. p. 24-7.
Iwueke AV, Nwodo OFC. Anti-hyperglycemic effect of aqueous extract of Daniella oliveri and Sarcocephalus latifolius roots on key carbohydrate metabolic enzymes and glycogen in experimental diabetes. Biokemistri. 2008; 20(2):63-70.
Jaeger JJ, Hedegaard H. Liver function tests and blood tests; 2002. Available:http://inet.tele.dk/omni/alttest.html. In: the Danish Hepatitis C website. Retrieved from http://home3
Jegede IA, Nwinyi FC, Muazzam I, Akumka DD, Njan AA, Shok M. Micromorphological, anti-nociceptive and anti-inflammatory investigations of stem bark of Daniellia oliveri. Afr J Biotechnol. 2006;5(10):903-35.
Johnston JK, Morris DD. Alterations in blood proteins. In: Smith BP, editor. International animal medicine. 2nd ed. Mosby Publishers; 1996.
Kabir M, Akpa GN, Nwagu BI, Adeyinka IA, Bello UI. Sexual dimorphism, breed and age characteristics of rabbits in Zaria, Nigeria. In: Proceedings of the 16th annual conference of Animal Science Association of Nigeria. 2011;133-7.
Keay RWJ. Flora of west tropical Africa. Crown agents for oversea governments and administrations; 1958.
Kyabayinze DJ, Tibenderana JK, Odong GW, Rwakimari JB, Counihan H. Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda. 2008;11:1-11.
Lamy C, Sauvan N, Renimel I, Andre P, Darnault S; 2010. Use in the cosmetics field of an extract of an exudate of the plant Daniella oliveri, in particular as an antiwrinkle agent. U.S. Patent No. 7,776,367. Washington, DC: US Patent and Trademark Office.
Laxminarayan R. Malaria among African children. 2006;25-8.
Keay RWJ. Flora of west tropical Africa. Crown agents for oversea governments and administrations; 1958.
Morassin B, Fabre R, Berry A, Magnaval JF. One year’s experience with the polymerase chain reaction as a routine method for the diagnosis of imported malaria. Am J Trop Med Hyg. 2002;66 (5):503-8.
Muanda N, F, Dicko A, Soulimani R. Chemical composition and biological activities of Ficus capensis leaves extracts. J Nat Prod. 2010;3(1):147-60.
Nakayoma J, Yamada M. Suppression of active oxygen-indeed cyto toxicity by flavonoids. Biochem Pharmcol. 1995;45: 265-7.
Negi J, S, Singh P, Rawat B. Chemical constituents and biologicalimportance of Swertia: A review. Curr Res Chem. 2011; 3:1-15.
Nwaeze CU, Abariku PO. Antimicrobial activity of certain medicinal plants used in traditional medicine in Nigeria. Niger J Microbiol. 2006;6(12):32-40.
Obun CO, Adeyemi OA. Effects of raw and toasted Daniellia oliveri Rolfe seed meal as replacement for groundnut meal on the performance of broiler chickens. Rev Cient UDO Agric. 2012;12(4):947-54.
Ogni CA, Kpodekon MT, Dassou HG, Boko CK, Koutinhouin BG, Dougnon JT et al. Inventaire ethno-pharmacologique des plantes utilisées dans le traitement des pathologies parasitairesdans les élevagesextensifsetsemi-intensifs du Bénin. Int J Biol Chem Sci. 2014;8(3): 1089-102.
Okunade SA, Olafadehan OA, Isah OA. Fodder potential and acceptability of selected tree leaves by goats. Anim Nutr Feed Technol. 2014;14(3):489-98.
Okwu D, E. Phytochemicals and vitamin content of indigenous spices of South Eastern Nigeria. Journal of sustenance of Africa Environment. 2004;6:30-4.
Onoja SO, Madubuike GK, Ezeja MI. Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniellia oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats. J Basic Clin Physiol Pharmacol. 2015;26(5):465-70.
Onwukaeme DN, Udoh F. Anti-ulcer activity of stem bark of Daniellia oliveri. Niger J Nat Prod Med. 1999;3(1):39-41.
Purves WK, Sadava D, Orians GH, Heller HC. Life: the science of Biology. Sinauer Associates and W H Freeman (7th Ed., p.954); 2003.
Reiter P. From Shakespeare to defoe: malaria in England in the little ice age. Emerg Infect Dis. 2000;6(1):1-11.
Reyburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: A prospective study. Br Med J. 2004;329 (7476):1212.
Schnell MA, Hardy C, Hawley M, Propert KJ, Wilson JM. Effect of blood collection technique in mice on clinical pathology parameters. Hum Gene Ther. 2002;13(1): 155-61.
Kitchen AD, Chiodini PL. Malaria and blood transfusion. Vox Sang. 2006;90 (2):77-84.
She RC, Rawlins ML, Mohl R, Perkins SL, Hill HR, Litwin CM. Comparison of Immunofl uorescence antibody testing and two enzyme immunoassays in the serologic diagnosis of malaria. J Travel Med. 2007;14(2):105-11.
Sinclair D, Zani B, Donegan S, Olliaro P, Garner P, Sinclair D et al. Artemisinin-based combination therapy for treating uncomplicated malaria [review]; 2009.
Soetan KO, Akinrinde AS, Ajibade TO. Preliminary studies on the haematological parameters of cockerels fed raw and processed guinea corn (Sorghum bicolor). Proceedings of the 38th annual conference of Nigerian Society for Animal Production; 2013;49-52.
Sofowora E, A. Medicinal plants and traditional medicine in Africa spectrum books Ltd Ibadan; Nigeria. 2008;1-10.
Swan H, Sloan L, Muyombwe A, Chavalitshewinkoon-Petmitr P, Krudsood S, Leowattana W et al. Evaluation of a real-time polymerase chain reaction assay for the diagnosis of malaria in patients from Thailand. Am J Trop Med Hyg. 2005;73 (5):850-4.
Taha K, El-Dein SD, Idrees M, Makboul G, Baidas G. Hematological changes in malaria in relation to Plasmodium species. Kuwait Med J. 2007;39(3):262-7.
Tangpukdee N, Duangdee C, Wilairatana P, Krudsood S. Malaria diagnosis: A brief review. Korean J Parasitol. 2009;47(2):93-102.
Trease G, E, Evans W, C. Pharmacognosy. 15th ed. London: Saunders Publishers. 2002;42-4, 221-9, 246-9, 304-6, 331-2, 391-3.
Ugwuene MC. Effect of dietary palm kernel meal for maize on the haematological and serum chemistry of broiler turkey. Niger J Anim Sci. 2011;13:93-103.
Ukaegbu CO, Nnachi AU, Mawak JD, IC. Incidence of concurrent malaria and typhoid fever infections in febrile patients in Jos, Plateau State, Nigeria. Int J Sci Technol Res. 2014;3(4):157-61.
Willcox ML, Gilbert B. Traditional herbal medicines for malaria. Br Med J. 2004;I (329):1156-9.
World Health Organization. New Perspect Malar Diagn. 2000;14(October 1999):29.
World Health Organization. The world Malaria Report [cited October 2019]. Available from: http://rbm.who.int/wmr. Geneva: WHO; 2005.
World Health Organization. World malaria report. Available:http://www.who.int/malaria/world/malaria/report2011/en/. Geneva: World Health Organization; 2011a.
World Health Organization. Quality control for herbal medicines. Geneva: WHO; 2011b.
World Health Organization. Global malaria programme. Eliminating malaria. Geneva: World Health Organization. World Health Organization. p. 243; 2015. Available:http://www.who.int/malaria/publications/world-malaria-report-2015/ report/en/.
World Health Organization. World malaria report 2017; 2017.
Sirabana ULIBALY, Anthelme NBS, Flavien TRAORE. Anti-inflammatory activity of the aqueous extract of Daniellia oliveri (Fabaceae). IAIM,. World malaria report 2019. In: Yaya ST, Claude MJ, Editors. 2016;3(2). Available:https://www.who.int/news-room/fact-sheets/detail/malaria. Vol. 2019. WHO
Regional Office for Africa. World Malaria Report. 2019;1-9.
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