Association of Sub-Clinical Hypothyroidism with Abnormal Levels of Lipid in the Population of Nawabshah, Pakistan
Nasrullah Aamer *
Department of Medicine, Peoples University of Medical and Health Sciences, Nawabshah, Pakistan.
Beenish Ghafar Memon
Department of Biochemistry, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Abdul Rashid
Department of Medicine, GMMC Teachig Hospital, Sukkur ,Pakistan.
Dayaram Makwana
Department of Cardiology, Mohamad Bin Khlifa Bin Salman Al Khalifa Cardiac Centre (MKCC), Kingdom of Bahrain.
Shahzad Memon
Department of Medicine, Peoples University of Medical and Health Sciences, Nawabshah, Pakistan.
Waseem Raja Memon
Department of Medicine, Peoples University of Medical and Health Sciences, Nawabshah, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Aims: Aim of this investigation was to access the association of dyslipidemia with subclinical hypothyroidism.
Methodology: In this cross-sectional investigation, 1948 participants were recruited. Two groups were made; participants up to 18 years were in group A and Subjects over 18 years were incorporated in group 2. They were subdivided into control, subclinical hypothyroid 1, and subclinical hypothyroid 2. SPSS 21 was used for data analysis.
Results: Data of 1619 individuals were analyzed. The mean age of Group A participants was 12.79 ± 2.779, and the mean age of Group B participants was 42.58 ± 18.012. The prevalence of subclinical hypothyroid was found at 13.5 %. Significant differences have been observed while comparing Group A and Group B (P <0.001). Free tetraiodothyronine and Free triiodothyronine also showed a significant difference in both groups. (P<0.05). No significant difference between mean Thyroid-stimulating hormone levels was observed (P>0.05). No significant association between Controls and High-density Lipid values was found between Controls and subclinical hypothyroid.
Conclusion: We conclude that subclinical hypothyroidism leads to increased dyslipidemia. Lower Serum total cholesterol and low-density lipid levels were detected among children and participants under the age of 18 with Thyroid-stimulating hormone greater than 10 mIU/L. Thyroid-stimulating hormone less than 10.0 mIU/L had no lipid abnormalities in subclinical hypothyroid participants.
Keywords: Dyslipidemia, HDL, LDL, sub clinical hypothyroidism