Serological Changes of Monoclonal Antibody CAMA3C8 against Human Breast Cancer Cell Line
N. Muninathan *
Department of Research, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Enathur, Kanchipuram, 631552, Tamil Nadu, India.
K. Ponnazhagan
Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Enathur, Kanchipuram, 631552, Tamil Nadu, India.
T. S. Meghalatha
Department of Research, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Enathur, Kanchipuram, 631552, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Tumor associated antigen are glycoproteins and glycolipids expressed on the surface or in the cytoplasm of tumor cells. The antigenic components are shed from the tumor cells into the tissue culture medium or blood or other human body fluids like human milk.
Objective: In the present study, investigate the serological assay of the antigen recognized by CAMA3C8 in patients with carcinoma of the breast.
Methods: The study is desgriptive cross section study.The study was divited into four groups based on the expression of tumor associated antigen.
Results: In breast cancer CAMA3C8 levels were significantly increased in stage 4 when compared with stage 1 breast cancer cell line.
Conclusion: In the present study, we conclude that significantly recognized CAMA3C8 defined antigens in breast cancer.
Keywords: Monoclonal antibody, breast cancer, tumor associated antigen, serological techniques