Insulin Resistance in Type II Diabetes Mellitus Patients and Their First Degree Relatives- An Observational Study
Aarti Sati *
Department of Pharmacology, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar Dehradun Uttarakhand, India.
Amit Varma
Department of Medicine, Shri Guru Ram Rai Institute of Medical and Health Sciences, Shri Guru Ram Rai University, Patel Nagar Dehradun. Uttarakhand, India.
Neeraj Kumar
Department of Pharmacology, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar Dehradun Uttarakhand, India.
Tariq Masood
Department of Biochemistry, Shri Guru Ram Rai Institute of Medical and Health Sciences, Shri Guru Ram Rai University, Patel Nagar Dehradun. Uttarakhand, India.
*Author to whom correspondence should be addressed.
Abstract
Type II diabetes (T2DM) is caused by environmental, genetic, metabolic, and unknown variables. In diabetics, insulin resistance is the most of prolonged hyperglycemia. T2DM is induced by insulin resistance and cell dysfunction. The interaction of genetics and environment further complicates T2DM development. Insulin resistance and beta cell dysfunction are two of the most common Type 2 Diabetes Mellitus symptoms. A vicious triangle of cell failure (80% cell function) and insulin resistance in the muscles and liver causes major physiological issues. A group of diabetes patients (Group I), non-diabetic first-degree relatives of diabetic patients (Group II), and a non-diabetic healthy control group (Group III) were studied. The diabetes patients had the greatest systolic and diastolic blood pressures, followed by first degree relatives and healthy controls. We found that people with diabetes had higher fasting (FBS) and postprandial sugar, glycated haemoglobin (HbA1c) than diabetic offsprings and control group. Moreover, fasting insulin levels are higher in first degree relatives than in diabetes patients in the control group. The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) levels of diabetics and their progeny do not differ much. The HOMA-IR measures insulin resistance severity. Common reference levels for HOMA-IR insulin resistance range from 0.7 - 2. Insulin resistance in diabetics and their first-degree relatives is evident from the results.
Keywords: First degree relatives, Insulin resistance, HOMA-IR, pancreatic beta cells, metabolic syndrome