A Rare Case of Adult Medulloblastoma Associated with Multiple Sclerosis: Case Report and Literature Review
Assem S. Alrumeh *
Pathology and Clinical laboratory Medicine Administration, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
Waleed A. Alkhalifah
Medical college Al Imam Muhammed Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
Abdulrahman Y. Alturki
Department of Adult Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
Zubair Syed
Department of Radiology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
Wafa Al shakweer
Pathology and Clinical Laboratory Administration Department, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
*Author to whom correspondence should be addressed.
Abstract
Medulloblastomas are the most common primary malignant brain tumors in childhood. They are responsible for around 20–40% of all brain tumors in children. They rarely occur in adulthood, but here they only make up less than 1% of all brain tumors. The standard therapy consists of an operation in combination with radiation and chemotherapy, which are individually determined for the patient. In this article, we discuss a case of 47 years old female patient diagnosed with primary progressive multiple sclerosis since 1 year. After 3 months of the diagnosis, she deteriorated and became unable to walk. MRI showed a large patchy enhancing midline cerebellar mass with evolving hydrocephalus. Tumor expressed positive reaction with synaptophysin immunohistochemical stain rendering medulloblastoma diagnosis.
Keywords: Medulloblastoma, multiple sclerosis, adult brain tumor