Antioxidant Studies of Thiazole Ring Bearing Chalcone Derivatives
Ashok Babu Kasetti *
Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Pacific University, Udaipur 313003, India and Dr. Samuel George Institute of Pharmaceutical Sciences, Markapuram, Andhra Pradesh 523316, India.
Jayesh Dwivedi
Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Pacific University, Udaipur 313003, India.
Ravindra Nagasuri
A.M. Reddy Memorial College of Pharmacy, Narasaraopeta, Andhra Pradesh 523316, India.
*Author to whom correspondence should be addressed.
Abstract
Oxidative stress is one of the common problems seen in a variety of diseases. Chalcones and in particular heteroaryl chalcones had reported with promising antioxidant activities. Hence, in the present work, we reported the antioxidant activity of twenty thiazole ring bearing chalcone derivatives (1-20). Among the tested compounds, compounds 17, 19 and 20 containing 2-pyridinyl, 3-pyridinyl and 2-thiazolyl scaffolds showed superior antioxidant activity than the standard with their IC50 values 4±1µg/mL, 3±1 µg/mL and 5±1 µg/mL respectively. The compound 19 is an interesting lead for the development of newer antioxidant agents.
Keywords: Oxidative stress, chalcones, heteroaryl chalcones, antioxidant activity