Contemporary Updates on the Role of Mast Cells in Oral Lesions: A Review
Vidya G. Doddawad *
Department of oral Pathology and Microbiology, JSS Dental College and Hospital, A constituent college of JSS Academy of Higher Education & Research, Mysore-570022, Karnataka, India.
Shivananda S
Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital, A constituent college of JSS Academy of Higher Education & Research, Mysore-570022, Karnataka, India.
Vidya C.S
Department of Anatomy, JSS Medical College and Hospital, A constituent college of JSS Academy of Higher Education & Research, Mysore-57002, Karnataka, India.
Parinitha MS
Department of Conservative Endodontics, JSS Dental College and Hospital, A Constituent College of JSS Academy of Higher Education & Research, Mysore-570015, India.
Seema Mehdi
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher education & Research, Mysuru 570015, Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
Mast cell (MCs) is considered the immune cell of myeloid lineage and make a crucial role in the inflammatory process in several types of oral diseases. This mast cell contains 50–200 large granules which are inflammatory mediators, including rich in histamine and heparin. It is mainly found in the connective tissues of the oral mucosa like nerves, blood vessels, and subepithelial areas of the human body. These cells have a key role in the maintenance of many physiologic functions of the body and thus their number was altered in various pathophysiologic diseases of the oral cavity such as benign and malignant tumors, reactive lesions, autoimmune diseases, odontogenic cyst, tumors, etc. The present paper is focused on the current concept and updates on the role and function of mast cells in physiologic and pathologic conditions of the oral cavity.
Keywords: Mast cells, oral mucosa, oral pathology, histamine, interleukins, angiogenesis effect