Synthesis, Anti Cancer and Anti Fungal Studies of New Phenyl Ethylene Derivatives
V. S. R. N. Phanikumar
Department of Chemistry, GITAM Institute of Science, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India.
M. Kiranmai Reddy
Department of Environmental Science, Institute of Science, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India.
G. Veera Raghava Sharma *
Department of Chemistry, GITAM Institute of Science, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Synthesis of Phenyl ethylene derivatives (4a-4f ) are reported in this communication. Products were characterized by1HNMR, Carbon (13C) NMR and Mass spectral data. Synthesized compounds of 4a-4f were screened for anti cancer and anti fungal activities and their results are presented. The main intermediate (3) was prepared from 4-methoxy phenyl acetone (1) reacted with aqueous ethylamine and NaBH4 to get the compound (2).Further dehydrohalogenation of (2) with 4-bromobutanol and potassium carbonate at 80°C resultedin compound (3)which on further dehydration with p-toluene sulfonic acid under reflux conditionsgave 4a to 4f.
Keywords: Anti cancer, antifungal, Synthesis, 4-Methoxy phenyl acetone, derivatives and characterization