A Review on: Smart Polymers used in Novel Ophthalmic Drug Delivery System
Amol Tagalpallewar *
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Survey No.124, Kothrud, Pune, India.
Shivani Chakankar
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Survey No.124, Kothrud, Pune, India.
Kalpesh Patil
SSR College of Pharmacy, Sayli Road, Silvassa, DNH, India.
Akshay Baheti
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Survey No.124, Kothrud, Pune, India.
Manish Wani
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Survey No.124, Kothrud, Pune, India.
Satish Polshettiwar
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Survey No.124, Kothrud, Pune, India.
*Author to whom correspondence should be addressed.
Abstract
Loss of sight or vision loss are utmost concerned worldwide health problems resulting in significant financial and public loss. Eyesight helps one to capture signals from the surrounding environment and depict clear visual images. Drug delivery to the eyes has been seen as a significant task for the reason that an eye has different defensive boundaries and drug clearance system resulting from an exceptional structural and functional nature of eyes. Formulation administered into the eye in the form of regular ophthalmic formulations leads to less absorption of drug. Therefore, approaches have been carried out to advance a novel, nontoxic and effective ophthalmic drug delivery system to control the difficulties occurring by the regular formulations. Latest innovation in pharmaceutical drug design has produced stimuli responsive in-situ gel system providing continuous release action and increased ocular drug bioavailability. They act by undergoing phase conversion from solution to gel owing to the variation in ocular temperature, ions and pH in the ocular environment. Stimuli transformed gel is formed in the region of cul de sac thus combating the limitations of regular ophthalmic formulations such as less retention time and fast nasolacrimal drainage within the eyes.
Keywords: In-situ gel, controlled release, pH responsive polymers, temperature responsive polymers, ion responsive polymers