The Uses and Application of Platelet Rich Fibrin in Clinical Practice
Kapil D. Bhangdiya *
Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha 442001, Maharashtra, India.
Deepankar Shukla
Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha 442001, Maharashtra, India.
*Author to whom correspondence should be addressed.
Abstract
Platelet derivatives are commonly used in wound healing and tissue regeneration. Different procedures of platelet preparation may differentially affect growth factor release and cell growth. Preparation of platelet-rich fibrin (PRF) is accompanied by release of growth factors, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor b1 (TGFb1), and several cytokines. When compared with the standard procedure for platelet-rich plasma (PRP), PRF released 2-fold less PDGF, but 415-fold and 42-fold VEGF and TGF b1, respectively.
Keywords: Wound healing, platelet rich fibrin, bone regeneration