The Effects of Plasma Exchange on Diffuse Alveolar Hemorrhage in Severe Vasculitis – A Case Study
Monali Rajendrakumar Sahu *
Midas Multispeciality Hospital, Nagpur, Maharashtra, India.
Tanvi Dilip Wairagade
HBT Medical College and Dr. R N Cooper Hospital, Mumbai, Maharashtra, India.
Sonali Dilip Wairagade
Department of Kayachikitsa, Datta Meghe Ayurved Medical College Hospital and Research Centre, Wanadongri, Nagpur, Maharashtra, India.
Ranjit S. Ambad
Department of Biochemistry, Datta Meghe Medical College, Shalinitai Meghe Hospital & Research Centre Wanadongri, Hingana, Nagpur-441110, Maharashtra, India.
Parikshit Muley
Department of Physiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe), Wardha, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Rapidly progressive glomerulonephritis (RPGN) and widespread alveolar hemorrhage define ANCA-associated vasculitis (AAV), a rare, life-threatening illness (DAH).
Case Presentation: An elderly female came with lower limb weakness and oliguria had features suggestive of RPRF and fluid overload. She developed hemoptysis with respiratory failure despite hemodialysis and intravenous steroids. The diagnosis of patients was pulmonary-renal syndrome– DAH in the setting of ANCA and based on the HRCT chest and positive p-ANCA report. She had excellent responses to intravenous pulse steroids, cyclophosphamide, and plasma exchange.
Conclusion: Based on observation showed the importance of immediate intervention in potentially fatal disease DAH in AAV.
Keywords: ANCA, AAV-ANC, DAH, PE, RPGN