Phytochemical Constitutents and Antidiabetic Property of Cola nitida Seeds on Alloxan-Induced Diabetes Mellitus in Rats
Iliemene Uju Dorathy *
Department of Biochemistry, Bingham University, Karu, Nigeria.
Shekins O. Okere
Department of Biochemistry, Bingham University, Karu, Nigeria.
Eze Ejike Daniel
Department of Physiology, Bingham University, Karu, Nigeria.
Liman Labaran Mubarak
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
The seeds of Cola nitida were investigated for their anti-diabetic properties. The extracts were obtained by maceration in cold water. Alloxan was used to induce diabetes mellitus (DM) in the rats at 180mg/kg body weight and diabetes was confirmed after 48 hours. The Phytochemical analyses of the plants showed the presence of tannin, flavonoid, terpernoid, cardiac-gylcoside, and alkaloids. Anthraquinone and saponin were observed to be absent. Cola nitida was also observed to cause a reduction in blood glucose level from 599±0.667mg/dl (diabetic control) to 170±0.577mg/dl (extract treated group). The extract showed a significant (P<0.05) decrease of blood glucose level in alloxan induced diabetic rats. Cola nitida aqueous extract showed a higher level of potency when compared to a known anti-diabetic drug (Glanil).
Keywords: Antidiabetic, diabetes mellitus, phytochemical, Cola nitida