Cytotoxic and Anticancer Activities of Indoline-2,3-dione (Isatin) and Its Derivatives
Sulayman A. Ibrahim
Pharmaceutical Chemistry Department, Faculty of Pharmacy, International University of Africa, P.O.Box 2469, Khartoum, Sudan.
Tilal Elsaman *
Department of Pharmaceutical Chemistry, College of Pharmacy, Omdurman Islamic University, P.O.Box 2547, Khartoum 11452, Sudan.
*Author to whom correspondence should be addressed.
Abstract
Isatin (1H-indolin-2,3-dione) is a versatile bioactive and heterocyclic scaffold with an indole nucleus. For the past decades, isatin and its derivatives have shown tremendous interest among researchers (organic and medicinal chemists). Hence, their extensive structural modification has result in different analogues of isatin depicting wide range of biological and pharmacological activities including antimicrobial, anticancer, anti-inflammatory and analgesic, anticonvulsant, anti-viral, anti HIV and antiplasmodial activity. In this present review, we focus on isatin and its derivatives possessing cytotoxic and anticancer activity against different cancer cell lines from the period 2002 to 2015.
Keywords: 1H-indolin-2, 3-dione, scaffold, cytotoxic activity, medicinal chemists, cancer cell lines.