Platelet Transfusion and Tranexamic Acid in the Treatment of Bleeding in Dengue Fever

Jamshed Saddique *

Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan.

Madeeha Ghaffar

Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan and Department of Medicine, Fatima Jinnah Medical University Lahore, Pakistan.

Muhammad Raffey Shabbir

Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan.

Azeem Khalid

Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan.

Asad Ur Rehman

Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan.

Muhammad Osama

Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan.

Abdullah Adil

Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan and Department of Medicine, King Edward Medical University Lahore, Pakistan.

*Author to whom correspondence should be addressed.


Abstract

Objective: We conducted this study to investigate the effectiveness of platelet transfusion and/or intravenous tranexamic acid in the treatment of clinical bleeding in patients with dengue fever at a tertiary care hospital during a large outbreak (August and November, 2011) of dengue fever in Lahore, Pakistan.

Methods: We reviewed data of patients with clinical bleeding and confirmed dengue fever at Jinnah Hospital Lahore, Pakistan. Based on the treatment, patients were classified into four groups: Baseline characteristics of patients and site and grade of bleeding were documented. A comparison of time to cessation of bleeding across four groups was made.

Results: Out of 100 selected patients with clinical bleeding, 65 were male and median age was 28 years (range 13-80). There were 47 patients in group A, 12 in group B, 9 in group C, and 32 in group D. 75 patients had bleeding from a single site while 24 patients had bleeding from 2 different sites and 1 patient had bleeding from 3 sites. Median time from the initiation of treatment till the cessation of bleeding was not significantly difference across four groups (p value = 0.724, Kruskal-Wallis test). Adverse effects included abdominal pain in group A and pruritus in group A and C.

Conclusion: Platelet transfusion and/or tranexamic acid do not provide significant benefit over standard of care treatment in patients with clinical bleeding in dengue fever and may be associated with adverse outcome.

Keywords: Dengue fever, dengue hemorrhagic fever, platelet transfusion, tranexamic acid, bleeding, Pakistan


How to Cite

Saddique, J., Ghaffar, M., Shabbir, M. R., Khalid, A., Rehman, A. U., Osama, M. and Adil, A. (2022) “Platelet Transfusion and Tranexamic Acid in the Treatment of Bleeding in Dengue Fever”, Journal of Pharmaceutical Research International, 34(39B), pp. 58–65. doi: 10.9734/jpri/2022/v34i39B36248.

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