Proniosomes: Non-Ionic Surfactant Coated Vesicular Carrier Systems with Effective Drug Targeting
Santosh Kumar Rada *
GITAM Institute of Pharmacy, GITAM (Deemed to be University) Visakhapatnam, Andhra Pradesh, India.
Gokula Brijitha
GITAM Institute of Pharmacy, GITAM (Deemed to be University) Visakhapatnam, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Proniosomes is one of the unique drug delivery technology wherein the medicament is enclosed in a vesicle and have a variety of medicinal and cosmetic applications. Vesicular drug delivery reduces the treatment cost by increasing the bioavailability of the drug, especially for sparingly soluble compounds. Proniosomes are easier to create and less expensive than other innovative formulations. Proniosomes improve medication stability and give significant accessibility in dosage, distribution, passage, and storage, demonstrating that proniosomes stand as a very promising drug carrier technology. This study emphasizes proniosome preparation procedures in general, and also its submissions in drug delivery and targeting. As well, this review broadly elucidates the potential of proniosomes in delivering drugs via different routes, such as oral, oral mucosal, dermal and transdermal, ocular, parenteral, pulmonary, intranasal, and vaginal. Lastly, a comparison of proniosomes versus niosomes demonstrates the fundamental differences between them. According to the findings, this system seems to be a prospective forthcoming drug carrier that might be scaled up for commercial use with physicochemical stability.
Keywords: Vesicular drug delivery, niosomes, proniosomes, proniosomal gel, drug carrier, advantages, characterization, applications