Prevalence of Non-motor Clinical Features of Parkinson Disease in Pakistan
Jaiperkash Moolchandani *
Department of Neurology, Hamdard Medical University and Hospital, Karachi, Pakistan.
Geeta Moolchandani
Department of Neurology, Sindh Government Lyari General Hospital, Karachi, Pakistan.
Shaima Sultana Memon
Department of Pathology, Dow Medical College, Karachi, Pakistan.
Humera Khalid
Department of Neurology, Sindh Government Lyari General Hospital, Karachi, Pakistan.
Faisal Ali Baloch
Department of Dental Material, Baqai Medical University, Karachi, Pakistan.
Faizah Mughal
Department of Biochemistry, Fazaiya Ruth Pfau Medical College, Karachi, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Aim: To highlight the frequency of non-motor clinical features in patients of Parkinson’s disease in Pakistan.
Study Design: Descriptive cross-sectional study
Place and Duration of Study: Study was conducted at the neurology ward of Jinnah postgraduate medical center, Karachi during August 2019 to February 2020.
Methodology: The study participants were having age >50 years but <70 years and were diagnosed case of Parkinson's disease. Demographic data including; age, gender, residence, and duration of symptoms were collected on the preformed proforma. Depression was diagnosed by using ICD-10 while anxiety and sleep disturbance were diagnosed by using BAI and DSM-IV respectively. Data was entered into SPSS version 20.
Results: The mean ± SD of age of patients was 59.26 ± 5.95 years. The mean ± SD duration of symptoms among these patients was 2.67 ± 2.04 months while mean ± SD of MMSE (mini mental status examination) score was 24.29 ± 1.59. About two thirds (62.86%) of patients were of age 50-60 years. Male to female ratio was 1.69: 1. The main outcome variable of this study was frequency of non-motor clinical features of Parkinsonism, it was noted that depression was more prevalent with frequency of 54.3%, anxiety was 41.4% and insomnia was present in 32.9% patients of Parkinson’s disease.
Conclusion: There is a high frequency of non-motor clinical symptoms particularly depression, anxiety and insomnia among patients of Parkinson’s disease with frequency of 54.3%, 41.4% and 32.9% respectively.
Keywords: Parkinson’s disease, non-motor clinical symptoms, depression, anxiety, insomnia