Deranged Haematological Profile and Dyslipidaemiain Diabetes Induced Nephropathy
Ghazal Mansoor
Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan and Sharif Medical and Dental College, Lahore, Pakistan.
Tahir Muhammad
Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.
Faheem Hadi
Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.
Tahir Maqbool *
Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.
Sana Qanber Abbasi
Sharif Medical and Dental College, Lahore, Pakistan.
Tania Ahmed Shakoori
Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan.
Arif Malik
Faculty of Sciences, University of Minhaj, Lahore, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Background: Diabetic nephropathy caused by complication of diabetes mellitus and frequently increasing in the developed countries. It may be characterized by dyslipidaemia and deranged haematological indices that play a role in the development of late complications of diabetes. Therefore, there is an urgent need to develop strategies to diagnose the patients of diabetic nephropathy during its acute phase.
Objective: To determine the haematological indices and the lipid profiles in diabetic nephropathy in comparison with diabetic controls
Methodology: The present study was performed on total of 300 patients where 150 DN patients and 150 control with age range from 30-50 years. The haematological profile was done via ABX Micros 60 haematology analyser, analysis of lipids, fats and fatty substances lipid panel was also performed in both groups. Statistical analysis was done with SPSS through t-test where p≥ 0.05.
Results: Current data indicated that the level of Haemoglobin A1c, Prothrombin time, White blood cells, platelet count, Low density lipoproteins and triglyceride is raised while significant reductions in red blood cell count and high-density lipoprotein levels have been noted in patients with diabetic nephropathy compared to diabetics.
Conclusion: Our research indicates that both haematological and lipid profiles are highly disturbed in DN patients which may serve as a hallmark for early diagnosis of nephropathy in diabetics.
Keywords: Diabetic Nephropathy (DN), End-stage Renal Disease (ESRD), Diabetes Mellitus (DM), LDL, HDL