Study on Molecular Basis of Cancer Induced Angiogenesis
Adithi Sanikommu
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Sai Akshita Vaddi
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Vandana Yeddula
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Lakshmi Saatvika Manikyala
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Chaitanya Krishna Kommineni
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Lakshmi Prasanna Sanikommu
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Susmitha Rani Talla
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Praveen Kumar Vemuri *
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Cancer is a disease caused by defective cells that have an uncontrollable ability to proliferate without regard for the physiological organ. Cancer is a complicated multi-factorial, multi-staged, and multi-mechanistic disease. Within the initiation and course of manifestation, it comprises the interaction of environmental and host elements. Inherited genetic dispositions have a significant role in 5-10% of breast cancer cases and 5- 13% of colon cancer cases. Viral infections cause about 7% of cancer fatalities in developed countries; 4% are due to occupational hazards; 2% are due to sunlight; 2% are due to pollution of air, water, and soil; and less than 1% are due to food components and business products.
Keywords: Etiology, epidemiology, cancer, angiogenesis, MMP, hypoxia