A Study of Controlled Release of Nano Particle Liquid Medicated Formulation using the RP-HPLC Method for Determination of Norethindrone into Dissolution Media
G. Lino Steffy Aster
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, 600 117, Tamil Nadu, India.
M. Vijey Aanandhi
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, 600 117, Tamil Nadu, India.
S. Rama Chandran *
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, 600 117, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
The determination of norethindrone can be done using a variety of approaches. Both sophisticated and validation strategies are included in this technique. The purpose of this research was to improve and test a smooth overturned segment-excessive standard performance liquid chromatographic technique for assessing norethindrone in dissolution media. The column is a C18 column from Thermo Scientific (250 mm x 4.6mm ID, 5m length). Deionized water, acetonitrile (50:50, v/v), and 5 ml/l acetic acid was made up with the cellular phase. The detecting wavelength was changed to 245 nm and the glide rate was changed to 1.3 ml/minute. The basic approach that was utilised was to investigate norethindrone release from a nanoparticle liquid medication device (LMF). The results showed that the procedure has become easy, precise, and particular.
Keywords: Norethindrone, chromatography, drugs and formulations, drug estimation, drug content material