Recent Approaches of Drugs and Vaccines Used in COVID 19: A Review
S. Sivakumar *
Department of Pharmacy, Annamalai University, Tamilnadu, India.
K. Kathiresan
Department of Pharmacy, Annamalai University, Tamilnadu, India.
P. Pandian
Department of Pharmacy, Annamalai University, Tamilnadu, India.
*Author to whom correspondence should be addressed.
Abstract
A novel SARS-CoV-2 coronavirus developed in December 2019, triggering a life-threatening pneumonia outbreak in China, and has since expanded worldwide, producing a pandemic. Because of the urgent need to control the disease and the dearth of specific and effective treatment options, FDA-approved medicines that have proven efficacy against comparable viruses are being used. In vitro, chloroquine, remdesivir, lopinavir/ritonavir or ribavirin are effective at inhibiting SARS-CoV-2. The preliminary findings of a variety of clinical trials utilising various chloroquine or hydroxychloroquine delivery procedures all indicate a positive outcome. They may not be effective in cases of consistently high viremia, and data on ivermectin (another antiparasitic medication) is currently unavailable. Intriguingly, azithromycin, a macrolide antibiotic, in conjunction with hydroxychloroquine may provide therapeutic benefits. Favipiravir, tocilizumab, and azithromycin types are among the other treatment options being investigated.
Keywords: SARS-CoV 2, MOA, drugs, vaccines