Lactate Dehydrogenase Enzyme Level in Women with Severe Preeclampsia: A Cross-sectional Study
Nadia Hameed
Sindh Government Pediatric Hospital Phuleli, Hyderabad, Pakistan.
Yasmeen Bibi
Hazrat Khadija Hospital latifabad, Pakistan.
Shehreen Memon
Bhittai Government Hospital Latifabad, Hyderabad, Pakistan.
Sanam Channa
CMW School Tando Muhammad Khan, Pakistan.
Muhammad Ali Memon
Department of Medicine, LUMHS, Hyderabad, Pakistan.
Muhammad Nadeem Chohan *
Pediatric Department, LUMHS, Jamshoro, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Aim: To determine the frequency of raised lactate dehydrogenase enzyme in women with severe preeclampsia.
Study Design: Cross-sectional study.
Place and Duration: Obstetrics and Gynecology department at Liaquat University Hospital Hyderabad from June 2018 to December 2018.
Methodology: There were 141 primiparous women with severe preeclampsia, included in this study. After taking history regarding hypertension and obstetrical examination, patients were subjected to a relevant investigation that is, 5ml of blood sent to an institutional laboratory for the measurement of lactate dehydrogenase enzyme, if it is >400 U/L then it was labeled as raised.
Results: The frequency of raised lactate dehydrogenase enzyme (400 U/L) was 13.48% (19/141) women with severe preeclampsia.
Conclusion: About 14% of women having Pre-eclampsia had raised lactate dehydrogenase enzyme. Severe preeclampsia is associated with severe multisystemic involvement. Raised LDH levels are indicative of cellular damage and severe hypertension in pregnancy.
Keywords: Preeclampsia, lactate dehydrogenase, hypertension, women, pregnancy