A Review on Role of Zebrafish in Huntington’s Disease
Bhumi Chaturvedi
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Shambaditya Goswami
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Hemant Bareth *
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Akhilesh Patel
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Rajesh Kumar Sharma
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Deepak Nathiya
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Arjav Jain
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Nikita Pal
Department of Pharmacy Practice, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
*Author to whom correspondence should be addressed.
Abstract
Treatment and effective therapies of most of the neurodegenerative disease are not available due to social and economic factors which makes it incurable. Huntington’s disease is one of such disease. Huntington’s disease (HD) is an inherited condition which leads to progressive degeneration of nerve cells may leads to cognitive, behavioral, and psychiatric symptoms. Discovery of zebrafish has filled the gap between in vitro and in vivo assays and makes the study of neuroscience easy with less complications. Zebrafish model has become a recent topic to focus on, as its utility in the study of neurological disease and role in improving screening methods makes the treatment and therapies more productive. Zebrafish hold many advanced functional genomics like human disease, the understanding of genetics, neurodegenerative disease and disorders and the discovery of therapeutics. It assess the mutant gene, etiology of human’s disease, and it is role in the disease progression and allows the identification of relevant treatment for the same. This review highlights the role of the zebrafish in the Huntington’s disease.
Keywords: Huntington’s disease, zebrafish, neuroscience, neurodegenerative disease, therapeutics