Neuroprotective Effects of Lantana camara in BPA Induced-cognitive Dysfunction and Oxidative Stress in Rats
I. Neelam *
Gitam Deemed to be University, Vishakapatnam, India.
Abhisek Pal
Gitam School of Pharmacy, Gitam Deemed to be University, Hyderabad, India.
*Author to whom correspondence should be addressed.
Abstract
The present study was aimed to screen neuroprotective effects of lantana camara in BPA induced-cognitive dysfunction and oxidative stress in rats. In methodology animals were divided into 5 groups. Group I serve as vehicle control group and was administered with 2 ml of normal saline. Group II was administered with BPA 50 µg/kg for 21 days. Group III and IV served as drug treated group and pre treated for 1 week with methanolic extract of L.camara (250 and 500 mg/kg bw/day orally). Group V serve as standard drug treated group and treated with piracetam 200mg/kg i.p. after the completion of dosing, rats were subjected to various test to analyze their behaviour performance and later sacrificed for further test. Animals were screened for elevated plus maze and Y-maze. Animals were sacrificed and evaluated the brain anti oxidant parameters like catalase (CAT), Estimation of lipid peroxidation (LPO), Estimation of superoxide dismutase (SOD), and Estimation of glutathione (GSH). All the Parameters of extract treated group animals have shown better results when compared with toxic and test groups. These findings provide a preliminary evidence for its potential as neuroprotective effect.
Keywords: Lantana camara, piracetam, elevated plus maze, Y-maze and anti oxidant, Bisphenol A.