A Review on Anthracycline Induced Cardiotoxicity- A Mechanism-based Approach

Sachin M. Hiradeve

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Vaibhav P. Uplanchiwar *

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Namrata Mane

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Gayatri Katole

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Sanjana N. Gaikwad

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Mayuri N. Deshmukh

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Swati G. Gaikwad

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Priya V. Nikam

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Abhinav Bais

Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur, 441110, Maharashtra, India.

Vijendra Fulzele

School of Pharmacy, G. H. Raisoni University, G. H. Raisoni Nagar, Saikheda, District Chhindwara, 480106, Madhya Pradesh, India.

Trupti S. Bobade

Reschrone Medico Publisher, Nagpur, Maharashtra, India.

Mohd. Hashim Mansoori

M. S. College of Pharmacy, Kudus Taq. Wada district Palghar, Maharashtra, India.

*Author to whom correspondence should be addressed.


Abstract

Doxorubicin has become one of the most effective chemotherapeutic agents, but its use was complicated by the development of heart failure. Proposed mechanisms for its antitumor effects included intercalation into DNA that caused the prevention of micro molecule synthesis, DNA cross-linkage and binding, DNA damage due to topoisomerase 2b suppression, reactive oxygen species production, and induction of apoptosis. Several drugs such as ACE inhibitors or the angiotensin receptor blockers, beta-blockers and the CHF therapy are used for the treatment processes. The present brief review of the literature, focuses on literature based on the mechanism of anthracycline-induced cardiotoxicity.

Keywords: Cytotoxicity, cardiotoxicity, anthracycline, doxorubicin, daunorubicin


How to Cite

Hiradeve, S. M., Uplanchiwar, V. P., Mane, N., Katole, G., Gaikwad, S. N., Deshmukh, M. N., Gaikwad, S. G., Nikam, P. V., Bais, A., Fulzele, V., Bobade, T. S. and Mansoori, M. H. (2022) “A Review on Anthracycline Induced Cardiotoxicity- A Mechanism-based Approach”, Journal of Pharmaceutical Research International, 34(7B), pp. 19–25. doi: 10.9734/jpri/2022/v34i7B35468.

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