Evaluation of Anti Inflammatory and Anti Oxidant Activities of Osbeckia crinite
Pallab Kalita
*
School of Pharmaceutical Sciences, University of Science and Technology Meghalaya, Baridua, Meghalaya, India.
Simanta Medhi
Crescent Institute of Pharmacy, Guwahati, Assam, India.
Sudarshana Borah
School of Pharmaceutical Sciences, University of Science and Technology Meghalaya, Baridua, Meghalaya, India.
G. K. Bhargav
School of Pharmaceutical Sciences, University of Science and Technology Meghalaya, Baridua, Meghalaya, India.
Faruk Alam
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Inflammation is a major condition associated with various diseases. Osbeckia crinita (Family- Melastomataceae) plants found in Meghalaya has the traditional beliefs to treat in the various disorders including various inflammatory disorders.
Objective: Evaluate the antioxidant and anti inflammatory activities of the leaves of Osbeckia crinita.
Methods: DPPH Radical Scavenging Activity and Carrageenan induced paw edema in mice.
Results: In the plant extract, various phytoconstituents are present including flavonoids, glycosides, alkaloids etc. Methanolic extract of Osbeckia crinita prominently showed free radical scavenging activities. The extract exhibited statistically significant inhibition of paw volume in a dose-dependent manner.
Conclusion: The study highlights the efficacy of Osbeckia crinita which is an ancient tradition, used in North eastern part of India. This ancient concept should be carefully evaluated in the light of modern medical science and can be utilized partially if found suitable.
Keywords: Osbeckia crinita, methanolic leaves extract, anti inflammatory activity