Implication of Estimated Glomerular Filtration Rate for an Effective Management in Type 2 Diabetes Mellitus
Nithya Panneerselvam *
Department of Pharmacology, Sree Balaji Medical College and Hospital, BIHER, India.
Hemanthkumar Shanmugam
Department of Pharmacology, Meenakshi Ammal Dental College and Hospital, MAHER, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Diabetic patients are at early risk of developing deterioration in renal function. The pharmacokinetics of antidiabetic drugs may get altered depending on the Glomerular filtration rate.
Aim: The aim is to study the estimated glomerular filtration rate eGFR appropriateness in the management of type 2 DM.
Materials and Methods: The study was conducted in the private diabetic care centre, Chennai. Serum urea, Serum creatinine, GFR and routine blood glucose investigations were measured for all the participants. Based on the report, the therapeutic modalities were analyzed for their nephroprotection. Descriptive statistics was used & values were expressed in numbers and percentage.
Results: Out of 148 patients, 87 diabetic patients were selected based on inclusion criteria. In which 55% were males & 45% females. Diabetes was observed to be highest 58.62% in the age group 40-59 years followed by 22.99% in 20-39 years and 18.39% in ≥60 years. 66 patients had creatinine level ≤1.1 and 21 patients had increased serum creatinine (>1.1). From the 87 study participants, 24 patient’s treatment regimens were modified based on eGFR and HbA1C.
Conclusion: Rationality in the management could be improved by including eGFR values in addition to glucose levels and HbA1C for type 2 diabetes mellitus.
Keywords: Hypoglycaemic agents, renal function tests, diabetic nephropathy