Screening of a Benzimidazole Derivative for Anthelmintic Activity with "Rule of 5" Approach
Chaitanya Prasad Meher *
School of Pharmacy, Centurion University of Technology & Management, Odisha, India.
Vijaya Kumar Meher
School of Pharmacy, Centurion University of Technology & Management, Odisha, India.
Dharmendra Pradhan
School of Pharmacy, Centurion University of Technology & Management, Odisha, India.
Ashish Kumar Meher
School of Pharmacy, Centurion University of Technology & Management, Odisha, India.
Subodha Chandra Sahu
The Pharmaceutical College, Barpali, Odisha, India.
Soumitri Sahu
The Pharmaceutical College, Barpali, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Purpose: Synthetic chemistry is an important route to develop new therapeutics for every disease. The presented research is focusing on the design, synthesis, evaluation, and Lipinski’s rule approach for a new biologically active benzimidazole derivative.
Methods: The synthesis comprises the reaction between lactic acid and o-phenylenediamine (OPD) to produce a corresponding product followed by self-condensation for obtaining a complex multiple.
Results: The newly produced composite was found to hold weighty anthelmintic property when we compared the same with Albendazole(Standard drug). When the concentration of the desired compound increases paralysis as well as death time found to decreases respectively. 50µg/ml of the synthesized drug gave a time for paralysis is 30.43 ± 5.33 min & time for death is 0.56 ± 5.32 min.
Conclusion: The synthesized final compound showed to have anthelmintic activity and its orally active property was also predicted from the Molinspiration software using physicochemical (RO5) as well as bioactive limits. It can be used for anthelmintic drugs as an oral formulation.
Keywords: Benzimidazole, self-condensation, anthelmintic activity, RO5