Anti Inflammatory Activity of Musa Sapientum and Its Mediated Copper Nanoparticles- An In Vitro Study
R. Akshaya
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.
S. Balaji Ganesh *
Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.
S. Rajeshkumar
Department of Pharmacology, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Musa sapientum commonly known as ‘banana’ is widely used in Indian folk medicine for the treatment of diabetes mellitus. Copper nanoparticles demonstrate a very strong catalytic activity, a property that can be attributed to their large catalytic surface area. The copper nanoparticles (Cu NPs) have been a strong focus on applications to health-related processes due to its antibacterial properties and antifungal activity in addition to their catalytic, optical, and electrical properties. The aim of the study is to check the anti-inflammatory activity of musa sapientum and its and it's mediated copper nanoparticles.
Materials and Methods: 1g of musa sapientum was weighed aseptically and then dissolved in 100ml of distilled water. Then the solution is boiled for about 5 minutes at a temperature of about 60-80 degree celsius and then allowed to cool down followed by filtration of extract and then copper nanoparticles were synthesised and anti inflammatory activity was done.
Results: It has been identified that, in 10µL concentration, the percentage of inhibition was noted as 43.5%, 20µL concentration shows 47.5% of inhibition, 30µL shows 83.6%, 40µL shows 85.4% and 50µL concentration shows 85.8% of inhibition which results in good anti inflammatory activity observed from 10 to 50µL concentration. From the study it can be clearly seen that a concentration dependent increase in the anti inflammatory activity was evident in copper nanoparticles and the standard in this study.
Conclusion : It has been concluded that the copper nanoparticles synthesised using the extract of musa sapientum have shown better anti-inflammatory activities.
Keywords: Copper nanoparticles, green synthesis, anti-inflammatory activities, musa sapientum, nanotechnology