A Review on Solubility Enhancement by Solid Dispersion Technique
Anchal Sharma *
School of Pharmacy, Abhilashi University Chailchowk, India.
Amit Chaudhary
School of Pharmacy, Abhilashi University Chailchowk, India.
Bhupendra Singh
Abhilashi College of Pharmacy, Nerchowk, India.
*Author to whom correspondence should be addressed.
Abstract
Approximately 30% of drug are lipophilic from all the newly discovered drug molecules and thus because of poor aqueous solubility fails to reach the market. In systemic circulation for achieving the desired therapeutic response solubility is one of the rate-limiting factors for orally administered drugs. The major challenge for the formulation scientist is to overcome the problem of solubility which can be achieved by using various technical approaches for the formulation product development. For enhancing the solubility of drugs Solid dispersion, micronization, and salt formation are some of the necessary approaches employed for enhancing the solubility of poorly soluble drugs and each approach has its merits and limitations. To deliver poorly soluble drugs novel technologies like Nanosuspension, Supercritical processing, and Cryogenic technologies may have various major opportunities. For the formulation development of new drug solubility behavior of any drug can be the most challenging aspect. The current review is focused on the solid dispersion technique for enhancement of solubility of drug which will be a novel technique for enhancing the solubility to diminish the amount of poorly soluble drug candidates eliminated from development and its characterization.
Keywords: Solid dispersion, bioavailability, solid dispersion generation, carrier selection, amorphous, crystalline