Journal of Pharmaceutical Research International

Introduction: Indian spices such as turmeric, ginger, and mint bring color and flavor to food and cure many ailments too.

Aim: To study the anti-inflammatory and antioxidant activity of white pepper oleoresin-mediated selenium nanoparticles.

Materials and Methods: The white pepper oleoresin extract was collected from Synthite Industries Pvt Limited, with a product code - 4010000835. Selenium nanoparticles were initially prepared using white pepper oleoresin and DPPH assay was performed on the different concentrations of white pepper oleoresin (10, 20, 30, 40, 50 μg/ml) for antioxidant activity, and anti-inflammatory activity was tested by the following method proposed by Muzushima and Kabayashi with specific alterations.

Results: White pepper has shown a very good anti-inflammatory effect and antioxidant activity when compared to the standard used at higher concentrations. Selenium nanoparticles appeared to have 90 percent inhibition in 50μL, which was also higher than the standard. Selenium nanoparticles seemed to have 85 percent inhibition in 50μL, which was also lower than the standard.

Conclusion: The present study has demonstrated an eco-friendly and cost-effective synthesis of Selenium nanoparticles using White pepper oleoresin. White pepper oleoresin mediated Selenium nanoparticles were with good anti-inflammatory and antioxidant activity which may be utilized include for its use in inflammatory and other conditions where there is a requirement for antioxidant activity.