Preparation and Evaluation of Matrix Tablet of Metronidazole Using Carnauba Wax
Matthew I. Arhewoh
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City 300001, Nigeria.
Sylvester O. Eraga *
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City 300001, Nigeria.
John A. Avbunudiogba
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria.
Queen Fregene
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria.
Paul Okah
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aim: To formulate a sustained release tablet dosage form of metronidazole using carnauba wax as matrix former and binder.
Methods: Batches of metronidazole tablets were formulated by using a combination of melt and wet granulation techniques. The formulated granules were evaluated for their flow properties, while the tablets for their friability, hardness, disintegration time and metronidazole release rate. The effect of varying concentrations of carnauba wax on the formulation was ascertained and compared with a conventional commercial product.
Results: The tablets had friability and hardness values ranging from 0.87-2.98% and 6.66 to 8.08 kp, respectively. Tablet weights did not vary significantly but the disintegration time varied from 2.61 to 4.86 min and the optimal batch of tablets released about 60% of its drug within 2 h as against that of the conventional tablet with a 100% release.
Conclusion: Carnauba wax can serve as a suitable binder to formulate a sustained release metronidazole tablets to achieve a reduction in the frequency of administration and consequently enhance compliance.
Keywords: Carnauba wax, metronidazole, sustained released, melt granulation.