Development and Characterization of Self-Nano Emulsifying Drug Delivery System of Ibuprofen
Z. S. Yahaya *
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria.
A. R. Oyi
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
T. S. Allagh
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
A. Abdulsamad
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aim: This work aimed to formulate self-nano emulsifying drug delivery systems (SNEDDS) for augmenting the biopharmaceutical performance of ibuprofen, a poorly-water soluble drug and subsequently evaluate its anti-inflammatory activity.
Methodology: Pseudoternary phase diagram studies facilitated selection of caprylic/capric glycerides as the oily phase, cremophor EL as surfactants, and polyethylene glycol-400 as the cosurfactant for formulating the SNEDDS. A stable combinations from the phase diagram consisting of 27% caprylic/capric glycerides, 58% cremophor EL and 15% polyethylene glycol-400 was loaded with ibuprofen and characterized with respect to globule size, polydispersity index (PDI), stability, emulsification time, % drug loading efficiency (DLE), in vitro drug release, infinite aqueous dilution, post-dilution drug precipitation and in vivo anti-inflammatory tests.
Results: The optimized ibuprofen SNEDDS (ibu-SNEDDS) had a mean globule size of 25.23nm, PDI of 0.093, showed excellent emulsification time of 5.0 s, released > 94% of the drug within 15 min while the pure drug showed only 8.8% drug release over a period of 1 h, exhibited no phase separation and demonstrated significantly (P < 0.05) higher anti-inflammatory effect than the reference drug.
Conclusion: Our study illustrated the potential use of SNEDDS as a promising nano drug carrier for the efficient delivery of ibuprofen that may solve the low bioavailability, high intra- and intersubject variability frequently associated with the oral delivery of the drug.
Keywords: Ibuprofen, anti-inflammatory, self-nano-emulsifying drug delivery system (SNEDDS), solubility.